Karcı, EbruÜrün, YükselKöksoy, Elif BernaUçar, GökhanBilgin, BurakYekedüz, EmreArslan, ÇağatayAlkan, AliDede, İsaTuncay, GülserenHocazade, CemilYıldırım Özdemir, NuriyeŞendur, Mehmet Ali NahitUtkan, GüngörYalçın, BülentAkbulut, Hakan2023-08-292023-08-292022Karcı, E., Ürün, Y., Köksoy, E. B., Uçar, G., Bilgin, B., Yekedüz, E. ... Akbulut, H. (2022). Predictive factor for lymph node metastasis in non-metastatic colorectal adenocarcinomas. Eurasian Journal of Medical Investigation, 6(3), 279-283. https://dx.doi.org/10.14744/ejmi.2022.370652602-3164https://dx.doi.org/10.14744/ejmi.2022.37065https://hdl.handle.net/20.500.12511/11374Objectives: To evaluate the predictive factors of lymph node involvement in non-metastatic colorectal adenocarcinomas (nmCRC). Methods: A total of 453 patients diagnosed with nmCRC were analyzed regarding T stage, lymphovascular invasion status, tumor grade and proposed risk score (RS), determined by the combination of these three factors for lymph node metastasis. Results: The median age was 62 (25-90 years), M/F ratio was 1.4:1 and majority of the patients had tumors localized on the left colon (70.6%). The number of excised lymph nodes was ?12 in 77% of the cases. The postoperative pathological assessments revealed that 57.2% of patie,nts had N0 disease, 29.1% had N1 disease, and 13.7% had N2 disease. The T stages (p=0.007), grade (p<0.001), lymphovascular invasion (p=0.002), RS (p<0.001), and number of excised lymph nodes (p=0.029) were significantly different between N0, N1, and N2 patients. Higher RS was associated with lymph node metastasis (p<0.001). Conclusion: The risk score may predict lymph node metastasis in patients with nmCRC and if validated may be helpful in the decision-making of adjuvant chemotherapy, especially in the elderly and patients with inadequate lymph node dissection.enAttribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccessColorectal AdenocarcinomasLymph Node MetastasisPredictive FactorArticle6327928310.14744/ejmi.2022.370651133889