Biltekin, Sevde NurKaradağ, Ayşe EsraDemirci, BetülDemirci, Fatih2022-12-152022-12-152022Biltekin, S. N., Karadağ, A. E., Demirci, B. ve Demirci, F. (2022). ACE2 and LOX enzyme inhibitions of different lavender essential oils and major components linalool and camphor. ACS Omega, 7(41), 36561-36566. https://doi.org/10.1021/acsomega.2c045182470-1343https://doi.org/10.1021/acsomega.2c04518https://hdl.handle.net/20.500.12511/10128In this present study, Lavandula angustifolia, Lavandula stoechas, and Lavandula x heterophylla essential oils and their main compounds linalool and camphor were evaluated in vitro for lipoxygenase enzyme (LOX) and for angiotensin converting enzyme 2 (ACE2) inhibition potential. The chemical compositions of L. angustifolia, L. stoechas, and L. heterophylla essential oils were confirmed both by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection, where 22.4, 0.9, and 30.6% linalool and 17.8, 54.7, and 15% camphor were identified for each oil among other components, respectively. Enzyme inhibitory activity studies were performed at 20 mu g/mL for the tested essential oils, whereas for linalool and camphor concentrations, 5 mu g/mL was used. The ACE2 inhibitions of L. angustifolia, L. stoechas, and L. heterophylla essential oils were 25.4, 34.1, and 27.1%, while the LOX inhibitions were observed as 79, 49.1, and 86.7%, respectively. In addition, linalool and camphor showed remarkable ACE2 inhibition with 77.1 and 85.1%, whereas the LOX inhibition was observed at 92 and 67.2%, respectively. In conclusion of the initial findings, further detailed in vivo studies are needed to confirm the safe use.eninfo:eu-repo/semantics/openAccessAntimicrobial AgentsInhibitionLipidsOrganic CompoundsPeptides and ProteinsArticle741365613656610.1021/acsomega.2c04518Q20008689508000012-s2.0-8513972610936278093Q1