Avnioğlu, SedaGüngör, MeltemKurutaş, ErgülÖztürk, ÜnalDemirhan, İlterBakariş, SevgiVelioğlu, Halil AzizÇankaya, ŞeydaYuluğ, Burak2022-03-032022-03-032022Avnioğlu, S., Güngör, M., Kurutaş, E., Öztürk, Ü., Demirhan, İ., Bakariş, S. ... Yuluğ, B. (2022). The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model. Revista Romana de Medicina de Laborator, 30(1), 9-18. https://doi.org/10.2478/rrlm-2021-00361841-66242284-5623https://doi.org/10.2478/rrlm-2021-0036https://hdl.handle.net/20.500.12511/9085Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.eninfo:eu-repo/semantics/openAccessResveratrolIschemia/Reperfusion InjuryAntioxidantOxidative StressHeartArticle30191810.2478/rrlm-2021-0036Q4000754348900001