Çelik, İstemi HanDemirel, GamzeUraş, NurdanO?uz, Şerife SunaErdeve, ÖmerDílmen, U?ur10.07.20192019-07-1010.07.20192019-07-102015Çelik, İ. H., Demirel, G., Uraş, N., O?uz, Ş. S., Erdeve, Ö., ve Dilmen, U. (2015). The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis. Archivos Argentinos de Pediatria, 113(6), 534-537. https://dx.doi.org/10.5546/aap.2015.eng.5340325-0075https://hdl.handle.net/20.500.12511/833https://dx.doi.org/10.5546/aap.2015.eng.534Introduction: In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis. Objective: To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology. Population and Methods: White blood cell count, IL-6 and CRP levels were compared among different groups. Results: Gram-negative, gram-positive and fungal infection groups consisted of 73, 82 and 15 patients, respectively. The optimal cut-off levels of IL-6 between gram-negative and gram-positive fungal infection groups were 202 and 57 pg/ ml. The fungal infection group had higher CRP levels than gram-negative and positive infection groups. Conclusions: To our knowledge, this is the largest reported study aiming at determining of IL-6 cut-off levels to differentiate neonatal sepsis aetiology. Gram-negative microorganisms led to 10 fold higher IL-6 production. The evaluation of IL-6 and CRP is useful to diagnose and also differentiate neonatal sepsis aetiology.eninfo:eu-repo/semantics/openAccessNewbornSepsisInterleukin-6C-reactive ProteinGramnegative InfectionsFungal DiseaseArticle113653453710.5546/aap.2015.eng.534Q4Q3