Battal, MuharremÇitgez, BülentKartal, AbdülcabbarKemik, AhuYıldırım, PınarÖzdenkaya, YaşarYılmaz, AhmetKaratepe, O?uzhan10.07.20192019-07-1010.07.20192019-07-102015Battal, M., Çitgez, B., Kartal, A., Kemik, A., Yıldırım, P., Özdenkaya, Y. ... Karatepe, O. (2015). Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model. Hepato-Gastroenterology, 62(138), 257-260. https://dx.doi.org/10.5754/hge149580172-6390https://dx.doi.org/10.5754/hge14958https://hdl.handle.net/20.500.12511/2611WOS: 000352115800002PubMed ID: 25916043Background/Aims: The purpose of our study is researching into impact of glucagon like peptide 1 (GLP 1) analogue on liver regeneration after major hepatectomy. Methodology: 24 wistar albino rats were consecutively divided into 3 groups. Group 1: Control (sham) group day 14 (n=8), Group 2: Liver resection group day 14 (n=8); 70% Liver resection was performed, Group 3: Study group day 14 (n=8); Subsequent to performing 70% liver resection, GLP-1 analogue was administered 2 times a day (10 mu gr/70 kg x 2 times). After 14 day, rats were sacrificed. Oxidative stress and antioxidant enzymes and mitochondrial permeability transition, cytochrome-c, Bax, Bcl-2, caspase-3, caspase-8 and caspase-3 activity were examined. Results: 70% Liver resection induced oxidative stress of liver tissue was ameliorated by GLP 1 induction. Administration of GLP increased Bcl-2 expression. Decreased expression of cytochrome-c was accompanied by a decrease caspase-3, caspase-8, and Bax expression and caspase-3 activity. Conclusions: Glp 1 induction plays a regenerative role in the major hepatectomy. This effect is dependent on modulation of the antiapoptotic and antioxidative pathways by GLP 1 expression.eninfo:eu-repo/semantics/openAccessGLP-1Liver ResectionOxidative DamageRegenerationArticle6213825726010.5754/hge14958Q4Q2