Çakal, BeytullahÇakal, SinemKaraca, OğuzKızılırmak Yılmaz, FilizGüneş, Hacı MuratYıldırım, ArzuÖzcan, Özgür UlaşGüler, YelizBoztosun, Bilal2022-12-262022-12-262022Çakal, B., Çakal, S., Karaca, O., Kızılırmak Yılmaz, F., Güneş, H. M., Yıldırım, A. ... Boztosun, B. (2022). Angio-seal used as a bailout for incomplete hemostasis after dual perclose ProGlide deployment in transcatheter aortic valve implantation. Texas Heart Institute Journal, 49(6). https://doi.org/10.14503/THIJ-21-76840730-2347https://doi.org/10.14503/THIJ-21-7684https://hdl.handle.net/20.500.12511/10183Background: The failure rate of vascular closure devices remains a significant cause of major vascular complications in contemporary transcatheter aortic valve implantation practice. Methods: This research aimed to evaluate use of the Angio-Seal device in a bailout context in the setting of incomplete hemostasis following use of dual Perclose ProGlide devices in patients undergoing transfemoral transcatheter aortic valve implantation. A total of 185 patients undergoing transfemoral transcatheter aortic valve implantation with either dual Per-close ProGlide (n = 139) or a combination of dual Perclose ProGlide and Angio-Seal (n = 46) were retrospectively analyzed. The baseline, procedural characteristics, and all outcomes (defined according to Valve Academic Research Consortium-2 criteria) were compared. Results: No significant differences were seen between the dual Perclose ProGlide vs dual Perclose ProGlide+Angio-Seal groups with regard to the in-hospital Valve Academic Research Consortium-2 primary end points of major vascular complications (n = 13 [9.4%] vs n = 2 [4.3%]; P =.36), minor vascular complications (n = 13 [9.4%] vs n = 8 [14.7%]; P =.14), major bleeding (n = 16 [11.5%] vs n = 2 [4.3%]; P =.25), and minor bleeding (n = 9 [6.5%] vs n = 5 [10.9%]; P =.34), with higher rates of hematoma in the dual Perclose ProGlide+Angio-Seal group (n = 4 [2.9%] vs n = 5 [10.9%]; P =.044). Conclusion: Finding from the current study suggest that adjunctive Angio-Seal deployment may be feasible and safe, especially in patients with incomplete hemostasis following dual Perclose ProGlide use, and can be an optimal “bailout” procedure. (Tex Heart Inst J. 2022;49(6):e217684).eninfo:eu-repo/semantics/openAccessPeripheral Artery DiseasesHemostasisVascular Access DeviceArticle49610.14503/THIJ-21-7684Q40008993592000012-s2.0-8514406667736515932Q3