Başpınar Küçük, HaticeAlhonaish, AnoudYıldız, TülayGüzel, Mustafa2022-07-212022-07-212022Başpınar Küçük, H., Alhonaish, A., Yıldız, T. ve Güzel, M. (2022). An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine. ChemistrySelect, 7(26). http://doi.org/10.1002/slct.2022013912365-6549http://doi.org/10.1002/slct.202201391https://hdl.handle.net/20.500.12511/9587An oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o was employed to synthesize new 2,5-disubstituted 1,3,4-oxadiazole compounds 4 a-d, 4 f-i, 4 k-n. This method involves oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o with molecular iodine mediated catalysis in which potassium carbonate served as a base. Characterization of all the synthesized novel compounds involved, proton and carbon NMR, mass spectrometry, and CHN elemental analysis. The synthesis of novel 2,5-disubstituted 1,3,4-oxadiazoles may display potential to provide pharmacologically important heterocyclic compounds.eninfo:eu-repo/semantics/embargoedAccessN-AcylhydrazonesOxidative Cyclization1,3,4-OxadiazolesMolecular IodineArticle72610.1002/slct.202201391Q30008219362000012-s2.0-85134028475Q2