Ünal, SemraEkren, NazmiŞengil, Ahmet ZekiOktar, Faik NüzhetIrmak, SterOral, ÖzlemŞahin, Yeşim MügeKılıç, Osman FatihAgathopoulos, SimeonGündüz, Oğuzhan10.07.20192019-07-1010.07.20192019-07-102018Ünal, S., Ekren, N., Şengil, A., Oktar, F., Irmak, S., Oral, Ö. ... Gündüz, O. (2018). Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 106(6), 2384-2392. https://dx.doi.org/10.1002/jbm.b.340461552-49731552-4981https://dx.doi.org/10.1002/jbm.b.34046https://hdl.handle.net/20.500.12511/1956WOS: 000442988800030PubMed ID: 29168913Hydroxyapatite (HA), obtained from bovine bones, was successfully reinforced with hexagonal boron nitrite (h-BN).h-BN/HA composites, with BN content up to 1.5 wt %, were sintered at various temperatures between 1000 and 1300 degrees C, in air. Well-sintered samples were obtained after sintering at 1200 and 1300 degrees C. The presence of h-BN contributed to dense, fine, and well-crystallized microstructure. The results of X-ray diffraction analysis and FT-IR spectroscopy showed that the produced composites comprised biphasic beta-TCP/HCA (HCA: carbonate partially substituted HA). High values of mechanical properties were achieved, namely compression strength 155 MPa for the sample 0.5% h-BN/HA and Vickers microhardness of 716 HV for the samples 1.5% h-BN/HA, both sintered at 1300 degrees C. U2OS human bone osteosarcoma proliferation and cell viability showed no adverse effect in the presence of h-BN/HA, suggesting the potential use of the produced materials as safe biomaterials in bone tissue engineering.eninfo:eu-repo/semantics/embargoedAccessCompositesHydroxyapatiteBovine BoneHexagonal Boron NitrideBioceramicArticle10662384239210.1002/jbm.b.34046Q2Q2