Neelakandan, A. R.Bae, Ok-NamMajid, ArshadÇağlayan, Ahmet BurakRajanikant, G. K.2021-12-232021-12-232022Neelakandan, A. R., Bae, O.-N., Majid, A., Çağlayan, A. B. ve Rajanikant, G. K. (2022). Neuroprotective potential of carnosine in cerebrovascular diseases. International Journal of Peptide Research and Therapeutics, 28(1). https://doi.org/10.1007/s10989-021-10342-51573-31491573-3904https://doi.org/10.1007/s10989-021-10342-5https://hdl.handle.net/20.500.12511/8714The growing prevalence, the risk of disabilities, and the lack of effective causal or disease-modifying therapies make cerebrovascular disorders a serious burden. Carnosine, an evolutionarily conserved endogenous dipeptide and over-the-counter food supplement, has a wealth of evidence exhibiting potentially neuroprotective effects. It is a natural, multi-functional, non-toxic anti-glycating antioxidant found in high concentrations in human and mammalian muscle and brain tissues. The physiological presence of carnosine in the brain, ability to cross the blood-brain barrier, and evidence from in vitro, and in vivo studies all point to it as a promising neurotherapeutic agent for cerebrovascular disorders. This review is intended to provide a detailed overview of the neuroprotective role of carnosine in cerebrovascular diseases and summarize existing evidence from cell and animal studies.eninfo:eu-repo/semantics/embargoedAccessCarnosineIschemic StrokeHemorrhagic StrokeVascular DementiaNeuroprotectionArticle28110.1007/s10989-021-10342-5Q4Q3