Kaya, SerdarTurhan, UğurDağ, I.Polat, İbrahim2023-07-282023-07-282023Kaya, S., Turhan, U., Dağ, I. ve Polat, İ. (2023). Association of maternal serum Netrin-1 and Netrin-4 levels with placenta accreta spectrum. European Review for Medical and Pharmacological Sciences, 27(10), 4594-4600. https://dx.doi.org/10.26355/eurrev_202305_324661128-3602https://dx.doi.org/10.26355/eurrev_202305_32466https://hdl.handle.net/20.500.12511/11274OBJECTIVE: This study aimed to evaluate maternal serum Netrin-1 and Netrin-4 levels in pregnancies complicated with placenta accreta spectrum.PATIENTS AND METHODS: This cross-sec-tional study enrolled 49 pregnant women with the diagnosis of placenta accreta spectrum as the study group. Gestational age-matched 30 uncomplicated pregnant women with prior ce-sarean delivery and normal placentation were randomly selected as the control group. Mater-nal serum Netrin-1 and Netrin-4 levels were mea-sured between weeks 34 and 36 of gestation.RESULTS: There was no significant difference between the groups in terms of demographic characteristics. Maternal serum Netrin-1 levels were significantly lower in placenta accreta spec-trum cases compared with those in the control group (p=0.038). There was no significant differ-ence between the groups in terms of maternal se-rum Netrin-4 levels (p>0.05). There was a signif-icant negative correlation between maternal se-rum Netrin-1 levels and the number of prior ce-sarean deliveries (r=-0.313, p=0.005).CONCLUSIONS: The observed decrease in maternal serum Netrin-1 levels in placenta ac-creta spectrum cases associated with increased angiogenesis might be one of the factors in-volved in the pathophysiology of this disease.eninfo:eu-repo/semantics/embargoedAccessAngiogenesisNetrin-1Netrin-4Placenta Accreta SpectrumArticle27104594460010.26355/eurrev_202305_32466Q30010211871000312-s2.0-8516075131437259741Q2