Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range

Winnier, DiedreNorton, LukeKanat, MustafaArya, RuthFourcaudot, MarcelHansis-Diarte, AndreaTripathy, DevjitDeFronzo, Ralph A.Jenkinson, Christopher P.Abdul-Ghani, Muhammad10.07.20192019-07-1010.07.20192019-07-102014Winnier, D., Norton, L., Kanat, M., Arya, R., Fourcaudot, M., Hansis-Diarte, A. ... Abdul-Ghani, M. (2014). Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range. The Journal of Clinical Endocrinology and Metabolism, 99(9), 3444-3449. https://dx.doi.org/10.1210/jc.2013-28860021-972X1945-7197https://dx.doi.org/10.1210/jc.2013-2886https://hdl.handle.net/20.500.12511/3028WOS: 000342341400086PubMed ID: 24796924Aim: The aim of this study was to examine the relationship between whole-body insulin-mediated glucose disposal and the fasting plasma glucose concentration in nondiabetic individuals. Research Design and Methods: Two hundred fifty-three nondiabetic subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined glucose intolerance received a 75-g oral glucose tolerance test and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG and NGT individuals and was related to fasting and 2-hour plasma glucose concentrations in each group. Results: TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2-hour plasma glucose (PG; r = 0.40, P < .0001) but not with the fasting PG. When IFG and NGT individuals were stratified based on their 2-hour PG concentration, the increase in 2-hour PG was associated with a progressive decrease in TGD in both groups, and the TGD was comparable among NGT and IFG individuals. Conclusion: The present results indicate the following: 1) as in NGT, insulin-stimulated TGD varies considerably in IFG individuals; 2) the large variability in TGD in IFG and NGT individuals is related to the 2-hour PG concentration; and 3) after adjustment for the 2-hour proglucagon concentration, IFG subjects have comparable TGD with NGT individuals.eninfo:eu-repo/semantics/openAccessInsulin-Mediated GlucosePlasma GlucoseGlucoseStrong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance rangeArticle9993444344910.1210/jc.2013-2886Q1Q1