Nuhoğlu, ÇağatayHepkaya, EvrimÖnal, Zehra EsraAkıcı, NarinGürbüz, TamayAtasayan, VildanCeran, Ömer10.07.20192019-07-1010.07.20192019-07-102018Nuhoğlu, Ç., Hepkaya, E., Önal, Z. E., Akıcı, N., Gürbüz, T., Atasayan, V. ve Ceran, Ö. (2018). Immunomodulator effect of topical zinc oxide application in tuberculin skin test. Northern Clinics of Istanbul, 5(1), 37-40. https://dx.doi.org/10.14744/nci.2017.888962148-4902https://dx.doi.org/10.14744/nci.2017.88896https://hdl.handle.net/20.500.12511/3567WOS: 000433094100008PubMed ID: 29607430OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis.eninfo:eu-repo/semantics/openAccessPurified Protein DerivativeTuberculin Skin TestZincArticle51374010.14744/nci.2017.88896N/A