Özbek, HanefiYılmaz, Betül Sever10.07.20192019-07-1010.07.20192019-07-102017Özbek, H. ve Yılmaz, B. S. (2017). Anti-inflammatory and hypoglycemic activities of alpha-pinene. Acta Pharmaceutica Sciencia, 55(4), 7-14. https://dx.doi.org/10.23893/1307-2080.APS.055221307-2080https://hdl.handle.net/20.500.12511/1098https://dx.doi.org/10.23893/1307-2080.APS.05522The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using a probit analysis method. For the anti-inflammatory activity measurement seven different groups were established and alpha-pinene was administered in four different doses: 0.05, 0.10, 0.25 and 0.50 mL/kg. For the evaluation of hypoglycemic activity six different groups, consisting of diabetic and healthy mice, were established. The strongest anti-inflammatory activity of alpha-pinene was observed with a 0.50 mL/kg dosage. The median effective dose (ED50) value of alpha-pinene was found to be 0.039 mL/kg. In diabetic mice ?-pinene showed significant levels of hypoglycemic activity at the 2nd and 24th hours. LD50 level of ?-pinene was determined to be 2.076 mL/kg. As a result, we conclude that alpha-pinene is a molecule that displays hypoglycemic and anti-inflammatory activities.eninfo:eu-repo/semantics/openAccessAlpha-PineneAnti-Inflammatory ActivityHypoglycemic ActivityMiceRatsArticle55471410.23893/1307-2080.APS.05522Q4