The cancer of the bladder risk assessment score and mortality-survival relationship among patients who have undergone radical cystectomy in the Turkish urooncology association database

Tavukçu, Hasan HüseyinTinay, İlkerİzol, VolkanBaltacı, SümerTeke, KeremSüer, EvrenYücetaş, UğurYazıcı, SertaçAkan, Serkan2025-02-192025-02-192024Tavukçu, H. H., Tinay, İ., İzol, V., Baltacı, S., Teke, K., Süer, E. ... Şahin, B. (2024). The cancer of the bladder risk assessment score and mortality-survival relationship among patients who have undergone radical cystectomy in the Turkish urooncology association database. Bulletin of Urooncology, 23(2), 56-62. http://dx.doi.org/10.4274/uob.galenos.2024.2024.3.22147-2270http://dx.doi.org/10.4274/uob.galenos.2024.2024.3.2https://hdl.handle.net/20.500.12511/12888Objective: The Cancer of the Bladder Risk Assessment (COBRA) score is a practical method that can be used to predict survival in patients who have undergone radical cystectomy (RC). We aimed to evaluate COBRA scores in our patient group. Materials and Methods: Patients were classified according to tumor stage and lymph node (TLN) involvement; mortality rates and survival were analyzed according to both the TLN classification and COBRA score from the Turkish Urooncology Association database. The chi-square test and Fisher-Freeman-Halton Exact chi-square test were used to compare qualitative data as well as descriptive statistical methods. Cox regression analysis was used for multivariate analysis. Kaplan- Meier and log-rank tests were used for survival analysis. Results: There was a statistically significant difference between the COBRA scores and survival rates in terms of cancer-specific mortality according to TLN classification (p=0.000; p<0.05). A COBRA score of 6 was associated with a lower mortality rate than a COBRA score of 5. In the Cox regression analysis of cancer-related death, a one-unit increase in the COBRA score increased the cancer-related death rate 1.54-fold [hazard ratio (HR)=1.540; 95% confidence interval (CI)=1.402-1.691] (p<0.05). When the COBRA score was compared to 0, the highest risk was observed for COBRA 5. If the COBRA score was 5, the risk of cancer- related death increased 14.63 times (HR=14.627; 95% CI=7.041-30.385) (p<0.05). If the COBRA score was 6, the risk of cancer-related death increased by 11.54 times (HR=11.547; 95% CI=5.270-25.278) (p<0.05). Conclusion: The COBRA score increased, the prognosis worsened, and our results are consistent with the first validated study.eninfo:eu-repo/semantics/openAccessBladder CancerCystectomyPrognosisThe cancer of the bladder risk assessment score and mortality-survival relationship among patients who have undergone radical cystectomy in the Turkish urooncology association databaseArticle232566210.4274/uob.galenos.2024.2024.3.2Q4WOS:001292819300003