Baltacı, Saltuk BuğraTutkun, ErkutAyyıldız, MustafaAğar, ErdalArslan, GökhanMoğulkoç, RasimBaltacı, Abdülkerim Kasım2024-06-252024-06-252024Baltacı, S. B., Tutkun, E., Ayyıldız, M., Ağar, E., Arslan, G., Moğulkoç, R. ... Baltacı, A. K. (2024). The effect of chronic swimming exercise and vitamin e supplementation on bone element metabolism in epileptic rats. Archives of Neuropsychiatry, 61(2), 113-118. http://dx.doi.org/10.29399/npa.284951300-06671309-4866http://dx.doi.org/10.29399/npa.28495https://hdl.handle.net/20.500.12511/12648Introduction: This study aimed to investigate the effects of chronic swimming exercise and vitamin E administration on elemental levels in the bone tissue of epileptic rats. Methods: Forty-eight rats were divided into six groups: Control, Swimming, Swimming + vitamin E, Swimming + Epilepsy, Swimming + Epilepsy + vitamin E, and Epilepsy. Vitamin E was administered to the animals chronically by gavage at a dose of 500 mg/kg every other day for 3 months. Epileptiform activity was induced with penicillin in animals 24 hours after the last vitamin E intake. The exercise program consisted of daily 30-minute swimming sessions. At the end of the treatment period, the levels of calcium, chromium, copper, iron, magnesium, manganese, lead, and zinc (µg/gram tissue) in bone tissue samples were measured using an atomic emission device. Results: The results showed that all epileptic groups had significantly lower bone chromium levels compared to the control groups (p<0.05). The epileptic, and epileptic swimming groups had the lowest levels of bone calcium, magnesium, and zinc (p<0.05). Vitamin E administration resulted in a significant increase in bone calcium, magnesium, and zinc levels in the epileptic swimming group with vitamin E compared to the epileptic and epileptic swimming groups. (p<0.05). Conclusion: The findings of the study show that the administration of vitamin E improves calcium, magnesium, and zinc metabolism in the deteriorated bone tissue of the epileptic rat model.eninfo:eu-repo/semantics/openAccessBone Elemental MetabolismEpilepsyRatSwimming ExerciseVitamin EArticle61211311810.29399/npa.28495Q40012447418000042-s2.0-8519639847238868851Q3