Erşahan, ŞeydaÖzçelik, FatihŞirin, Dursun AliErdem Hepsenoğlu, YeldaÖzçelik, İlbey KayraTopbaş, Celalettin2023-10-052023-10-052023Erşahan, Ş., Özçelik, F., Şirin, D. A., Erdem Hepsenoğlu, Y., Özçelik, İ. K. ve Topbaş, C. (2023). Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease? Odontology, 111(3), 708-718. https://doi.org/10.1007/s10266-022-00767-91618-12471618-1255https://doi.org/10.1007/s10266-022-00767-9https://hdl.handle.net/20.500.12511/11529To investigate the relationship between apical periodontitis [AP] severity and inflammatory markers [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-?), and Mid-Regional Pro Adrenomedullin (MR-proADM)] in patients with AP. A total of 162 subjects were divided into three categories: AP group (n = 80), periodontitis (P) group (n = 42), healthy control group (n = 40). The scoring of disease severity in 80 AP patients without any periodontal disease, using dental radiographs, was based on “The Abscess Score” (AS), as those having at least 1 tooth with AP and severity of PAI 3–4 were classified as AS 1 (mild); those with only1 tooth and severity of PAI 5 as AS 2 (moderate) and those having > 2 tooth with severity of PAI 5 as AS 3 (severe). Blood samples were collected from all of the patients. Enzyme-linked immunosorbent assay was used to evaluate the samples. The MR-pro ADM levels of both the AP and P groups were considerably higher than the control group (p < 0.01). The IL-12 levels of the AP group were higher than the P and control groups (p < 0.05). TNF-? levels of the P group were significantly higher than both the AP and control groups (p < 0.01). MR-pro ADM levels of both the AP and Periodontitis groups were higher than the control group. TNF-? was a biomarker of periodontitis, while IL-12 was a biomarker of apical periodontitis.eninfo:eu-repo/semantics/embargoedAccessApical PeriodontitisChronic PeriodontitisIL-12Mid Regional ProadrenomedullinTNF-?Article111370871810.1007/s10266-022-00767-9Q30008864505000012-s2.0-8514222973336414882N/A