Karahan, NazımÖzdemir, GüzelaliKolukısa, DuyguDuman, SerdaArslano?lu, FatihÇetin, Mehmet2020-04-162020-04-162020Karahan, N., Özdemir, G., Kolukısa, D., Duman, S., Arslano?lu, F. ve Çetin, M. (2020). Can collagenase be used in the treatment of adhesive capsulitis? Medical Principles and Practice, 29(2), 174-180. https://dx.doi.org/10.1159/0005030861011-75711423-0151https://hdl.handle.net/20.500.12511/5131https://dx.doi.org/10.1159/000503086Background: The objective of this study was to evaluate the efficacy of subacromial injections of collagenase and corticosteroid in rats with experimentally induced adhesive capsulitis. Method: Thirty adult Wistar albino male rats were distributed into 3 groups of 10 rats each after stabilization of their shoulders for 3 weeks: the first group received a single dose of 0.002 mg (0.25 mL) subacromial collagenase; the second group received a single dose of 1.60 mg (0.25 mL) subacromial steroid, and the third group received a single dose of 0.25 mL subacromial saline solution. One week later, we investigated shoulder range of motions, collagen content of the shoulder, and joint cartilage structure. Results: There was no statistically significant difference in the cartilage damage between the groups (p > 0.05). Fibrosis measurements were significantly lower in the collagenase group than in the steroid and saline groups. There was no significant difference in fibrosis between the steroid and saline groups (p > 0.05). Abduction measurements were significantly higher in the collagenase group than in the steroid and saline groups (p < 0.001). No significant difference in the abduction measurements was observed between the saline and steroid groups (p > 0.05). Conclusion: We observed that subacromial injections of collagenase Clostridium histolyticum effectively treated adhesive capsulitis. The results suggest that this treatment could be considered for use in patients with an intact rotator cuff.eninfo:eu-repo/semantics/openAccessAdhesive CapsulitisCollagenaseExperimental StudyRatSteroidArticle29217418010.1159/000503086Q3Q3