Berk, BarkınAtlas Tahirovic, YeşimBülbül, Emre FatihBiltekin, Sevde Nur10.07.20192019-07-1010.07.20192019-07-102017Berk, B., Atlas Tahirovic, Y., Bülbül, E. F. ve Biltekin, S. N. (2017). The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives. Acta Pharmaceutica Sciencia, 55(3), 17-28. https://dx.doi.org/10.23893/1307-2080.APS.055161307-2080https://hdl.handle.net/20.500.12511/1100https://dx.doi.org/10.23893/1307-2080.APS.05516Benzothiazoles and 2-mercaptobenzothiazoles are important classes of bioactive organic scaffolds possessing antibacterial, antifungal, antitubercular, antiinflamma-tory, antidiabetic, and antimalarial properties. In recent years, prediction of drug-likeness, molecular, absorption, distribution, metabolism, and excretion (ADME) properties using in silico techniques has become a standard procedure for the evaluation of molecules in terms of their potential clinical use. In this study, compounds structured 6-benzoyl-3-substitutedmethylbenzo[d]thiazole-2(3H)-thione were synthesized using the Mannich reaction starting from 2-mercaptobenzothiazole. The antibacterial and antifungal activities of these compounds were determined against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans, Candida krusei, and Candida parapisilosis using a broth microdilution method. An additional analysis was undertaken using the in silico technique to predict the drug-likeness, molecular, and ADME properties of these molecules. Among all the compounds, respectively, Compounds 1-4 and 6-11 exhibited good minimum inhibition concentration values against Staphylococcus aureus and Candida species with promising predicted properties.eninfo:eu-repo/semantics/openAccessADMEAntifungalBenzothiazole-2-ThioneCandida AlbicansIn SilicoMolecular PropertiesArticle553172810.23893/1307-2080.APS.05516Q4