Yılmaz, İlhanEşeoğlu, MetehanÖnen, Mehmet ReşidTanrıverdi, OsmanKılıç, MustafaYılmaz, AdemMüslüman, Ahmet MuratAydın, Mehmet DumluGündoğdu, Cemal10.07.20192019-07-1010.07.20192019-07-102017Yılmaz, İ., Eşeoğlu, M., Önen, M. R., Tanrıverdi, O., Kılıç, M., Yılmaz, A. ... Gündoğdu, C. (2017). Inverse association between basilar artery volume and neuron density in the stellate ganglion following bilateral common carotid artery ligation: An experimental study. World Neurosurgery, 100, 138-143. https://dx.doi.org/10.1016/j.wneu.2016.12.0341878-87501878-8769https://dx.doi.org/10.1016/j.wneu.2016.12.034https://hdl.handle.net/20.500.12511/4094WOS: 000401930000017PubMed ID: 28007603OBJECTIVE: This study examined the relationship between neuron density in the stellate ganglion and the severity of basilar artery (BA) enlargement after bilateral common carotid artery ligation. METHODS: Rabbits (n = 24) were randomly divided into 3 groups: unoperated control group (n = 4), experimental group subjected to bilateral common carotid artery ligation (n [ 15), and sham-operated control group (n = 5). Histologic examination of the BAs and stellate ganglia was performed 2 months later. Permanent bilateral common carotid artery ligation was induced by ligation of common carotid arteries at prebifurcation levels as a model for steno-occlusive carotid artery disease. RESULTS: Mean BA volume and neuron density in stellate ganglia for all animals were 4200 mu m(3) +/- 240 and 8325 mu m(3) +/- 210. In sham- operated animals, the mean values were 4360 mu m(3) +/- 340 and 8250 mm(3) +/- 250. For the experimental group, mean volume and density in animals with slight dilatation of the BA (n = 6) were 4948 mu m(3) +/- 680 and 10,321 mm(3) +/- 120, whereas in animals with severe dilatation (n = 9), the values were 6728 mu m(3) +/- 440 and 6300 mm(3) +/- 730. An inverse association was observed between degree of BA enlargement and stellate ganglia neuronal density. CONCLUSIONS: High neuron density in stellate ganglia may protect against steno-occlusive carotid artery disease by preventing BA dilatation and aneurysm formation in the posterior circulatory arteries.eninfo:eu-repo/semantics/embargoedAccessBasilar ArteryBilateral Common Carotid Artery LigationNeuron Density in Stellate GanglionArticle10013814310.1016/j.wneu.2016.12.034Q3Q2