Kılıç, Fatma SultanKaygısız, BilginAydın, ŞuleYıldırım, CaferKarimkhan, HadiÖner, Setenay10.07.20192019-07-1010.07.20192019-07-102018Kılıç, F., Kaygısız, B., Aydın, Ş., Yıldırım, C., Karımkhan, H. ve Öner, S. (2018). Pregabalin attenuates carrageenan induced acute inflammation in rats by inhibiting proinflammatory cytokine levels. Eurasian Journal of Medicine, 50(3) 156-159. https://dx.doi.org/10.5152/eurasianjmed.2018.172611308-87341308-8742https://dx.doi.org/10.5152/eurasianjmed.2018.17261https://hdl.handle.net/20.500.12511/2362WOS: 000450354500005PubMed ID: 30515034Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats. Materials and Methods: Single doses of PGB 30, 50, and 100 mg/kg and indomethacin (INDO) 5 mg/kg in the treatment groups and saline in the control group were injected once intraperitoneally prior to administration of 100 mu l of 1% CAR into the right hind paw of the rats. The paw thickness was measured using gauge calipers (Vernier calipers) before (0 hour) and every hour afterwards for 6 hours following the inflammation induction. The cytokine levels in the blood serum obtained intracardiacally were determined after 6 hours using the enzyme-linked immunosorbent assay method. p < 0.05 was considered statistically significant. Results: There was no significant difference between the 0 and 6th hour considering the paw thickness in all groups, except in the CAR group. CAR significantly increased the paw thickness at 6 hours compared to the 0 hour. All doses of PGB and INDO significantly reduced the paw thickness after 6 hours compared to the CAR group. The TNF-alpha and IL-1 beta levels in the PGB and INDO groups were comparable to the control group, whereas in the CAR group, these levels were increased. The IL-10 level was enhanced in the PGB 50 mg/kg and INDO groups. Conclusion: It was observed that all doses of PGB exerted anti-inflammatory-like effects comparable to INDO, supported by their effects on the levels of cytokines.eninfo:eu-repo/semantics/openAccessPregabalinInflammationAnti-Inflammatory EffectCytokinesRatArticle50315615910.5152/eurasianjmed.2018.17261N/AQ3