Vardar, Mehmet AliGüzel, Ahmet BarışTaşkın, SelenGüngör, MeteÖzgül, NejatSalman, CoşkunKüçükgöz Güleç, ÜmranKhatib, GhadaTaşkıran, ÇağatayDünder, İlkkanOrtaç, FıratYüce, KunterTerek, CoşanŞimşek, TayupÖzsaran, AydınOnan, AnılÇoban, GoncaTopuz, SametDemirkıran, FuatTakmaz, ÖzgüçKöse, Mehmet FarukGöçmen, AhmetSeydaoğlu, GülşahGümürdülü, DeryaAyhan, Ali2021-11-302021-11-302021Vardar, M. A., Güzel, A. B., Taşkın, S., Güngör, M., Özgül, N., Salman, C. ... Ayhan, A. (2021). Could the long-term oncological safety of laparoscopic surgery in low-risk endometrial cancer also be valid for the high–intermediate-and high-risk patients? A multi-center turkish gynecologic oncology group study conducted with 2745 endometrial cancer cases. (TRSGO-End-001). Current Oncology, 28(6), 4328-4340. https://dx.doi.org/10.3390/curroncol280603681718-77291198-0052https://dx.doi.org/10.3390/curroncol28060368https://hdl.handle.net/20.500.12511/8593This study was conducted to compare the long-term oncological outcomes of laparotomy and laparoscopic surgeries in endometrial cancer under the light of the 2016 ESMO-ESGO-ESTRO risk classification system, with particular focus on the high–intermediate-and high-risk categories. Using multicentric databases between January 2005 and January 2016, disease-free and overall survivals of 2745 endometrial cancer cases were compared according to the surgery route (laparotomy vs. laparoscopy). The high–intermediate-and high-risk patients were defined with respect to the 2016 ESMO-ESGO-ESTRO risk classification system, and they were analyzed with respect to differences in survival rates. Of the 2745 patients, 1743 (63.5%) were operated by laparotomy, and the remaining were operated with laparoscopy. The total numbers of high–intermediate- and high-risk endometrial cancer cases were 734 (45%) patients in the laparotomy group and 307 (30.7%) patients in the laparoscopy group. Disease-free and overall survivals were not statistically different when compared between laparoscopy and laparotomy groups in terms of low-, intermediate-, high–intermediateand high-risk endometrial cancer. In conclusion, regardless of the endometrial cancer risk category, long-term oncological outcomes of the laparoscopic approach were found to be comparable to those treated with laparotomy. Our results are encouraging to consider laparoscopic surgery for high–intermediate- and high-risk endometrial cancer cases.enAttribution 4.0 Internationalinfo:eu-repo/semantics/openAccessHigh-Risk Endometrial CancerLaparoscopic SurgerySurvivalArticle2864328434010.3390/curroncol28060368Q3Q2