Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma

Naki, Mehmet MuratOran, GülbinTetikkurt, Seza ÜmitSönmez, Cavide FatmaTürkmen, İlknurKöse, Faruk10.07.20192019-07-1010.07.20192019-07-102017Naki, M. N., Oran, G., Tetikkurt, S. Ü., Sönmez, C. F., Türkmen, İ. ve Köse, F. (2017). Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma. Journal of the Turkish-German Gynecological Association, 18(3), 139-142. https://dx.doi.org/10.4274/jtgga.2017.00161309-03991309-0380https://dx.doi.org/10.4274/jtgga.2017.0016https://hdl.handle.net/20.500.12511/3334WOS: 000423954800008PubMed ID: 28890428Objective: To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). Material and Methods: Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The association of MELF pattern with age, tumor grade, depth of myometrial invasion, and presence of lymphovascular space invasion (LVSI) was analyzed. Results: FIGO grade 2 and grade 1 tumors were evident in 53.0% and 38.6% of patients, respectively. Depth of myometrial invasion was <50% in 72.0% of patients, and LVSI was absent in 77.1%. MELF pattern was confirmed in 35 (42.2%) patients. Presence of MELF pattern was associated with significantly higher mean +/- standard deviation age (62.9 +/- 6.9) years vs. 58.9 +/- 9.1 years, p=0.033), and found to be more likely in patients with high-grade tumor (FIGO grade III; 85.7% vs. 14.3%, p<0.001), deep (>= 50%) myometrial invasion (78.3% vs. 21.7%, p<0.001), and presence of LVSI (94.7% vs. 5.3%, p<0.001) as compared with absence of MELF pattern. Conclusion: In conclusion, our findings revealed a high rate of MELF pattern among patients with EEA alongside the association of MELF pattern with poor prognostic factors such as high grade tumor, deep myometrial invasion, and LVSI.eninfo:eu-repo/semantics/openAccessEndometrioid Endometrial AdenocarcinomaMicrocysticElongatedFragmented PatternTumor GradeMyometrial InvasionLymphovascular Space InvasionMicrocystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinomaArticle18313914210.4274/jtgga.2017.0016N/AQ3