Yalçınkaya, Ahmet S.Şekeroğlu, Mehmet RamazanHuyut, ZübeyirÇokluk, ErdemÖzbek, HanefiÖztürk, GürkanBalahoroğlu, Ragıp2023-01-172023-01-172022Yalçınkaya, A. S., Şekeroğlu, M. R., Huyut, Z., Çokluk, E., Özbek, H., Öztürk, G. ... Balahoroğlu, R. (2022). The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline. Archives of Physiology and Biochemistry, 128(3), 795-801. https://dx.doi.org/10.1080/13813455.2020.17275281381-34551744-4160https://dx.doi.org/10.1080/13813455.2020.1727528https://hdl.handle.net/20.500.12511/10318Objective: This study investigated the relationship between diabetes (DM) and nitrite, nitrate and MDA levels and effect of melatonin and pentoxifylline. Methods: Sixty mice were randomly divided into four groups. Control: no action; Diabetes group (DM): after fasting-blood-glucose (FBG) was measured, 150 mg/kg alloxane was applied intraperitoneally three-times every other day; Diabetes + Melatonin (DM + MLT) and Diabetes + Pentoxifylline groups (DM + PTX): following the same procedures with DM, 10 mg/kg melatonin and 50 mg/kg pentoxifylline were administered subcutaneously six days, respectively. Following FBG analysis, brain tissues were taken under the anaesthesia. Nitrite, nitrate and MDA levels were measured. Results: In the all groups with alloxane, FBG were higher than in before application (p <.05). Also, FBG, nitrite, nitrate and MDA levels in the DM + MLT and DM + PTX groups were lower than in the DM (p <.05). Conclusions: Nitrite and nitrate may be related to etiopathogenesis of DM, and pentoxifylline and especially melatonin relatively decrease nitrite, nitrate and lipid peroxidation.eninfo:eu-repo/semantics/embargoedAccessAlloxanDiabetes MellitusMelatoninOxidative StressPentoxifyllineArticle128379580110.1080/13813455.2020.1727528Q20005148814000012-s2.0-8507977014632070146Q3