Sakin, AbdullahÖzçelik, MahsunŞahin, SüleymanAydemir, OzanAldemir, Mehmet Naciİliklerden, Ümit HalukKotan, Mehmet Çetin2022-08-052022-08-052022Sakin, A., Özçelik, M., Şahin, S., Aydemir, O., Aldemir, M. N., İliklerden, Ü. H. ... Kotan, M. Ç. (2022). The prognostic effect of pretreatment 18F-FDG PET/CT metabolic parameters in locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Surgical Oncology-Oxford, 43. https://doi.org/10.1016/j.suronc.2022.1018090960-74041879-3320https://doi.org/10.1016/j.suronc.2022.101809https://hdl.handle.net/20.500.12511/9626Introduction: In this study, we aimed to examine the relation between pre-treatment 18F-FDG PET/CT metabolic parameters [(including the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG)] and treatment response and survival in locally-advanced Esophageal Squamous Cell Cancer (ESCC) treated with definitive chemoradiotherapy (dCRT). Methods: A total 76 patients with locally-advanced ESCC who received dCRT between June 2015 and December 2019 were included in this retrospective study. Patients were divided into two groups as complete response (CR) or non-complete response (Non-CR) according to response to treatment. AUC was obtained as 0.749 (p < 0.001) in the ROC curve drawn by MTV for the CR. The MTV value was <= 12 cm(3), with 72.1% sensitivity and 73.0% specificity. Results: Of the 76 patients, 38 (50%) were male and 38 (50%) were female. The median age was 62 (39-84) years. The treatment response in 35 (46%) patients was CR. MTV value was > 12cm3 in 41(54%) patients. Median follow-up time was 14.5 months. In patients with MTV > 12cm3, median progression-free survival(mPFS) and median overall survival(mOS) were 9 months and 11 months, respectively, whereas mPFS and OS could not be reached in those with MTV & LE;12 cm3 (p < 0.001 and p < 0.001, respectively). In patients with non-CR, mPFS and mOS were 8 months and 9 months, respectively, whereas mPFS and OS could not be reached in patients with CR (p < 0.001 and p < 0.001, respectively). In multivariate analysis, age (odds ratio [OR], 1.07), ECOG PS (OR, 11.1), and MTV (OR, 4.73) were found to be the factors affecting treatment response. Conclusion: In our study, treatment response and MTV were found to be the factors associated with survival in patients treated with dCRT, showing the pre-treatment MTV value as a predictor of treatment response.eninfo:eu-repo/semantics/embargoedAccessMetabolic Tumor VolumeTumor Lesion GlycolysisEsophageal CancerChemoradiotherapySquamous Cell CarcinomaArticle4310.1016/j.suronc.2022.101809Q30008284019000032-s2.0-8513489376735809492Q2