Günlüoğlu, GülşahSeyhan, Ekrem CengizKazancıoğlu, RumeyzaGünlüoğlu, ZekiŞimşek Veske, NurdanErtan Yazar, EsraAltın, Sedat2022-04-112022-04-112015Günlüoğlu, G., Seyhan, E. C., Kazancıoğlu, R., Günlüoğlu, Z., Şimşek Veske, N., Ertan Yazar, E. ... Altın, S. (2015). Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients. 54(5), 465-472. https://doi.org/10.2169/internalmedicine.54.32450918-29181349-7235https://doi.org/10.2169/internalmedicine.54.3245https://hdl.handle.net/20.500.12511/9281Objective Patients undergoing haemodialysis for chronic renal failure-hemodialysis (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed. Methods The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using QuantiFERON-TB Gold In Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared. Results TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (kappa=1). Conclusion Blood IP-10 level, which can be measured simply, provides results equivalent to IGRAs for the diagnosis of LTBI in CRF-HD patients.eninfo:eu-repo/semantics/openAccessLatent Tuberculosis InfectionChronic Renal FailureIP-10IGRATSTArticle54546547210.2169/internalmedicine.54.3245Q3WOS:000350745700005PMID: 25758071Q3