Berk, BarkınErtaş, MerveBiltekin, Sevde Nur10.07.20192019-07-1010.07.20192019-07-102017Berk, B., Ertaş, M. ve Biltekin, S. N. (2017). Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin. Acta Pharmaceutica Sciencia, 55(1), 83-96. https://dx.doi.org/10.23893/1307-2080.APS.05561307-2080https://hdl.handle.net/20.500.12511/1096https://dx.doi.org/10.23893/1307-2080.APS.0556Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, absorption, distribution, metabolism, and excretion (ADME) properties using in silico techniques has become a standard procedure for the evaluation of clinical usable molecules. In this study, Schiff base structured 2-methoxy-6-{[(2-alkyl/arylethyl)imino]methyl}phe-nol derivatives were synthesized from 3-methoxysalicylaldehyde (o-vanillin). The antibacterial and antifungal activities of these compounds were determined against Staphylococcus aureus, Escherichia coli, Candida albicans and Pseudomonas aeruginosa using agar-well diffusion and broth microdilution techniques. Further analysis was conducted using the in silico technique to predict the drug-likeness, molecular and ADME properties of these molecules. Among all the compounds, 2-{[(4-fluorophenethyl)imino]methyl}-6-methoxyphenol (Compound 9) exhibited the highest activity with good minimum inhibition concentration and radius of inhibition zone values against Candida albicans.eninfo:eu-repo/semantics/openAccessAntifungalCandida AlbicansIn SilicoMolecular PropertiesSchiff BasesArticle551839610.23893/1307-2080.APS.0556Q4