Karan, BelginErbay, GürcanKoç, ZaferPourbagher, AyşinYıldırım, SedatAğıldere, Ahmet Muhteşem10.07.20192019-07-1010.07.20192019-07-102016Karan, B., Erbay, G., Koç, Z., Pourbagher, A., Yıldırım, S. ve Ağıldere, A. M. (2016). Utility of diffusion-weighted MRI to detect changes in liver diffusion in benign and malignant distal bile duct obstruction: The influence of choice of b-values. Canadian Association of Radiologists Journal, 67(4), 395-401. https://dx.doi.org/10.1016/j.carj.2016.03.0060846-53711488-2361https://dx.doi.org/10.1016/j.carj.2016.03.006https://hdl.handle.net/20.500.12511/2114WOS: 000388250400013PubMed ID: 27592163Purpose: The study sought to evaluate the potential of diffusion-weighted magnetic resonance imaging to detect changes in liver diffusion in benign and malignant distal bile duct obstruction and to investigate the effect of the choice of b-values on apparent diffusion coefficient (ADC). Methods: Diffusion-weighted imaging was acquired with b-values of 200, 600, 800, and 1000 s/mm(2). ADC values were obtained in 4 segments of the liver. The mean ADC values of 16 patients with malignant distal bile duct obstruction, 14 patients with benign distal bile duct obstruction, and a control group of 16 healthy patients were compared. Results: Mean ADC values for 4 liver segments were lower in the malignant obstruction group than in the benign obstruction and control groups using b = 200 s/mm(2) (P < .05). Mean ADC values of the left lobe medial and lateral segments were lower in the malignant obstruction group than in the benign obstructive and control groups using b = 600 s/mm2 (P < .05). Mean ADC values of the right lobe posterior segment were lower in the malignant and benign obstruction groups than in the control group using b = 1000 s/mm(2) (P < .05). Using b = 800 s/mm(2), ADC values of all 4 liver segments in each group were not significantly different (P > .05). There were no correlations between the ADC values of liver segments and liver function tests. Conclusion: Measurement of ADC shows good potential for detecting changes in liver diffusion in patients with distal bile duct obstruction. Calculated ADC values were affected by the choice of b-values.eninfo:eu-repo/semantics/openAccessBiliary ObstructionDiffusion-Weighted ImagingLiver FibrosisMagnetic Resonance ImagingB-ValueArticle67439540110.1016/j.carj.2016.03.006Q3Q2