dc.contributor.author | Şakul, Ayşe Arzu | |
dc.contributor.author | Okur, Mehmet Evren | |
dc.date.accessioned | 2022-06-24T10:59:53Z | |
dc.date.available | 2022-06-24T10:59:53Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Şakul, A. A. ve Okur, M. E. (2022). Beta-sitosterol and its antinociceptive mechanism action. Journal of Faculty of Pharmacy of Ankara University, 46(2), 238-252. http://doi.org/10.33483/jfpau.882831q | en_US |
dc.identifier.issn | 1015-3918 | |
dc.identifier.uri | http://doi.org/10.33483/jfpau.882831q | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9540 | |
dc.description.abstract | Objective: In this study, the possible central antinociceptive activity of beta-sitosterol is investigated along with its association of stimulation of opioidergic, serotonergic, adrenergic, and cholinergic receptors to mice central analgesia because of the beta-sitosterol administration. Material and Method: The beta-sitosterol was administrated to mice in various doses, such as 5, 10 and 20 mg/kg. Then, the mice analyzed via hot-plate and tail-flick assay to investigate the possible antinociceptive effects of beta-sitosterol. Additionally, in order to associate the mechanism of action mechanism, 20 mg/kg of beta-sitosterol was intraperitoneally administered to the animal which were previously pre-treated with opioid antagonist naloxone (5 mg/kg), serotonin 5-HT2A/2C receptor antagonist ketanserin (1 mg/kg), serotonin 5-HT3 receptor antagonist – ondansetron (1 mg/kg), α2-adrenoceptor antagonist yohimbine (1 mg/kg) and muscarinic antagonist atropine (5 mg/kg), as well as nicotinic antagonist mecamylamine (1 mg/kg). Result and Discussion: The antinociceptive effect of beta-sitosterol was confirmed as dose-dependent for 5, 10, and 20 mg/kg doses in tail-flick and hot-plate tests. It can be concluded that beta-sitosterol promotes central antinociception effects associated with the spinal and supraspinal mediated cholinergic and opioidergic modulation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Ankara University | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antinociception | en_US |
dc.subject | Beta-Sitosterol | en_US |
dc.subject | Cholinergic Receptors | en_US |
dc.subject | Opioidergic Receptors | en_US |
dc.title | Beta-sitosterol and its antinociceptive mechanism action | en_US |
dc.title.alternative | Beta-sitosterol ve antinosiseptif etki mekanizması | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Faculty of Pharmacy of Ankara University | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-9354-0000 | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 238 | en_US |
dc.identifier.endpage | 252 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.33483/jfpau.882831q | en_US |
dc.institutionauthor | Şakul, Ayşe Arzu | |
dc.identifier.scopus | 2-s2.0-85131801768 | en_US |
dc.identifier.scopusquality | Q3 | en_US |