dc.contributor.author | Gemici, Aliihsan | |
dc.contributor.author | Bilgen, Hülya | |
dc.contributor.author | Erdoğan, Cem | |
dc.contributor.author | Kansu, Abdullah | |
dc.contributor.author | Olmuşçelik, Oktay | |
dc.contributor.author | Beköz, Hüseyin Saffet | |
dc.contributor.author | Dinleyici, Rümeysa | |
dc.contributor.author | Mert, Ali | |
dc.contributor.author | Sevindik, Ömür Gökmen | |
dc.date.accessioned | 2021-01-14T07:16:53Z | |
dc.date.available | 2021-01-14T07:16:53Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Gemici, A., Bilgen, H., Erdoğan, C., Kansu, A., Olmuşçelik, O., Beköz, H. S. ... Sevindik, Ö. G. (2020). A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma. Turkish Journal of Medical Sciences, 50(8), 1781-1785. https://dx.doi.org/10.3906/sag-2009-77 | en_US |
dc.identifier.issn | 1300-0144 | |
dc.identifier.issn | 1303-6165 | |
dc.identifier.uri | https://dx.doi.org/10.3906/sag-2009-77 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6239 | |
dc.description.abstract | Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Health authority in Turkey has published a guideline to integrate this promising option in the treatment process of patients who are prone to high risk of developing severe COVID-19.Materials and Methods: Forty consecutive patients who had received CP at our center were included in the study. Demographics, COVID-19 specific parameters, biomarkers to detect the severity of COVID-19 infection and outcome variables were collected retrospectively. The correlation between outcome variables and the independent predictors of the outcome were reported.Results: Median age of the patients was 57.5 and 72.5% were male. At least one COVID-19 PCR test was confirmed to be positive in 75% of patients. Remaining 25% had a Chest-CT which was reported to be compatible with an ongoing COVID-19. All patients (100%) were classified as having severe COVID-19 infection. Over a half of the patients harbored an oxygen saturation of less than 90 despite of a continuous 5 L/min support of O-2. 82.5% of the patients had a need for mechanical ventilation and 45.5% had a need for invasive mechanical ventilation. Nine out of 10 patients who have received CP outside ICU have totally recovered from COVID-19 at a median of 9 days, and a half of the patients who needed invasive mechanical ventilation were successfully free of mechanical ventilation support and managed to recover from COVID-19.Conclusion: According to the results of this study, CP is an efficient conjunct to conventional therapy against COVID-19 with a favorable safety profile. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Tübitak Scientific & Technical Research Council Turkey | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Convalescent Plasma | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Viral Infections | en_US |
dc.title | A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Turkish Journal of Medical Sciences | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3385-8359 | en_US |
dc.authorid | 0000-0002-7424-8688 | en_US |
dc.authorid | 0000-0002-5715-8138 | en_US |
dc.authorid | 0000-0001-8902-5498 | en_US |
dc.authorid | 0000-0002-9815-1848 | en_US |
dc.authorid | 0000-0003-1237-8281 | en_US |
dc.authorid | 0000-0001-8930-741X | en_US |
dc.authorid | 0000-0001-8945-2385 | en_US |
dc.authorid | 0000-0001-9636-4113 | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 1781 | en_US |
dc.identifier.endpage | 1785 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3906/sag-2009-77 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |