Güncel Gönderiler: Sağlık Hizmetleri Meslek Yüksekokulu
Toplam kayıt 77, listelenen: 21-40
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Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
(Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
Synthesis of novel oxadiazole derivatives and their cytotoxic activity against various cancer cell lines
(TUBITAK, 2022)Caffeic acid (CA), ferulic acid (FA) and caffeic acid phenethyl ester (CAPE) have a broad anticancer effect on various cell lines. In this study, nine ferulic and caffeic acid-based 1,2,4 and 1,3,4 oxadiazole molecular ... -
Rapid molecular diagnosis of group a streptococcus with a novel loop mediated isothermal amplification method
(Verlag Klinisches Labor GmbH, 2022)Background: Group A Streptococcus (GAS) is the most common bacterial cause of acute tonsillopharyngitis. In this study, it was aimed to evaluate the performance of a novel Loop Mediated Isothermal Amplification (LAMP) ... -
Enhancing memory capacity by experimentally slowing theta frequency oscillations using combined EEG-tACS
(Nature Portfolio, 2022)he coupling of gamma oscillation (similar to 40+ Hz) amplitude to the phase of ongoing theta (similar to 6 Hz) oscillations has been proposed to be directly relevant for memory performance. Current theories suggest that ... -
Modeling and simulation of the "IL-36 cytokine" and CAR-T cells interplay in cancer onset
(World Scientific, 2022)Background: CAR-T cells are chimeric antigen receptor (CAR)-T cells; they are target-specific engineered cells on tumor cells and produce T cell-mediated antitumor responses. CAR-T cell therapy is the "first-line" therapy ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases
(Elsevier Inc., 2022)Please modify the Abstract as follows:Here we tested if the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms from the eye-closed to the eyes-open condition may differ in patients with ... -
Ürün tanıtım temsilcilerinin yeterlilik eğitimindeki başarı düzeylerinin demografik özellikleriyle karşılaştırılması
(Hacettepe Üniversitesi, 2017)Tıbbi mümessiller ile ilgili ulusal ve uluslararası yapılan çalışmalar incelendiğinde; çalışmaların kısıtlı sayıdaki tıbbi mümessiller ile yapıldıkları ve tıbbi mümessil profilini yeterli düzeyde yansıtmadığı görülmüştür. ... -
Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates
(Frontiers Media SA, 2022)Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
(Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
(Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Protective effect of edaravone on rat testis after valproic acid treatment
(Marmara University, 2022)Valproic acid n-dipropyl-acetic acid, VPA) is a medication used as anticonvulsant in the treatment of bipolar disorder, and for migraine prophylaxis. Long-term use of VPA is known to trigger reproductive impairment, which ... -
Üniversite öğrencilerinde tütün kullanım alışkanlıklarının belirleyicileri ve algılar: İstanbul ilinde sağlık hizmetleri yüksekokulu öğrencileri örneği
(Atatürk Üniversitesi, 2021)Amaç: Sağlık Meslek Yüksekokulu öğrencilerinin tütün ve tütün ürünleri kullanma davranışlarını incelemek ve bu davranış üzerinde belirleyicifaktörleri ortaya koymaktır.Yöntem: Bu araştırma, Medipol Üniversitesi Sağlık ... -
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
(Elsevier B. V., 2022)In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ... -
The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach
(Bentham Science Publishers, 2022)Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA ... -
The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters
(Wiley, 2021)In this study, we aimed to evaluate whether edaravone (EDA) has a protective role against valproic acid (VPA)-induced lung damage via its antioxidative activity. Male Sprague-Dawley rats were split into four groups. Control ... -
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
(John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies
(Elsevier, 2021)New pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the ... -
Transforaminal epidural steroid injection for recurrent lumbar disc herniation
(Formerly Turgut Özal Medical Center, 2020)Aim: Transforaminal epidural steroid injection reduces the low back-leg pain which caused by lumbar disc herniation (LDH). The aim of our study is to evaluate the treatment of transforaminal epidural steroid injection for ...