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Osteoprotegerin genetic polymorphisms and their influence on therapeutic response to ibandronate in postmenopausal osteoporotic females
(Public Library of Science, 2023)ObjectivesThe present study investigated osteoprotegerin (OPG) genetic polymorphisms and their influence on the therapeutic response to ibandronate in postmenopausal osteoporotic females.MethodsThis case-control study ... -
Outcomes and complications from a randomized controlled study comparing conventional stent placement versus no stent placement after ureteroscopy for distal ureteric calculus < 1 cm
(MDPI, 2022)Ureteric stent insertion following ureteroscopic lithotripsy (URSL) is a common and widely accepted procedure. However, there is no agreement on whether a ureteric stent should be placed following an uncomplicated URSL. ... -
Over kanseri̇ne yöneli̇k fotodi̇nami̇k terapi̇ temelli̇ kombi̇nasyon terapi̇ uygulaması
(Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2018)Kanser, tüm dünyada olduğu gibi ülkemizde de en ölümcül hastalıkların başında gelmektedir. Kanserin, lokal, minimum yan etkiyle ve hedefe yönelik olarak tedavisi hasta için büyük önem taşımaktadır. Fotodinamik Terapi (FDT), ... -
Oxidative stress markers are increased in non-alcoholic fatty liver disease patients with high serum alanine aminotransferase levels
(Termedia Publishing House Ltd, 2019)Introduction: Non- alcoholic fatty liver disease (NAFLD) is a pathological disease that causes chronic damage in the liver without alcohol consumption. Aim of the research: To determine oxidative stress and inflammation ... -
Patient-reported outcome measures using modified urethral stricture surgery: Patient-reported outcome measure for direct visual internal urethrotomy and nontransecting urethroplasty for short nontraumatic bulbar urethral stricture - A prospective comparative observational study from a university teaching hospital
(Wolters Kluwer Medknow Publications, 2023)Purpose: To evaluate the patient-reported outcomes of primary direct visual internal urethrotomy (DVIU) and nontransecting bulbar urethroplasty techniques (NTBU) for the short segment (<2 cm) nontraumatic bulbar urethral ... -
Patient-specific induced pluripotent stem cells for cardiac disease modeling
(Walter de Gruyter GMBH, 2019)Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) via induction of pluripotency genes is one of the most influential scientific breakthroughs during the last decade. Behind this breakthrough ... -
Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
(Academic Press Inc., 2022)The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ... -
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
(Springer, 2022)Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ... -
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
(Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ... -
Physical and mental health characteristics of hospitalized covid-19 patients with and without type 2 diabetes mellitus in Turkey
(2024)The aim of this study was to assess the rates of depression, anxiety, and stress and quality of sleeping among COVID-19 patients with and without type 2 diabetes mellitus (T2DM). A case and control design has been employed, ... -
Poloxamer-188 and d-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles integrated orodispersible sublingual films to improve oral bioavailability of ebastine in vitro and in vivo characterization
(MDPI, 2021)Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and d-alpha-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability of ... -
A pooled RT-PCR testing strategy for more efficient Covid-19 pandemic management
(Elsevier, 2022)Objectives: RT-PCR testing is indispensable in Covid-19 pandemic management. With the spread of the pandemic with emerging variants, the RT-PCR capacity is overburdened and new strategies and capabilities need to be ... -
Post-COVID-19 pain syndrome: A descriptive study in Turkish population
(Korean Pain Society, 2022)Background: The new type of corona virus has a wide range of symptoms. Some people who have COVID-19 can experience long-term effects from their infection, known as post-COVID conditions. The authors aimed to investigate ... -
Post-trauma acinetobacter baumannii meningitis treatment approach
(Turkısh Assoc Trauma Emergency Surgery, 2024)Acinetobacter baumannii, associated with nosocomial infections, is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur after surgery or trauma. Our patient developed ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Pre-use ureteroscope contamination after high level disinfection: Reprocessing effectiveness and the relation with cumulative ureteroscope use
(Lippincott Williams and Wilkins, 2019)Purpose: We assessed the frequency of preoperative and persistent microbial contamination of flexible ureteroscopes after reprocessing and the relation of contamination to cumulative ureteroscope use. Materials and Methods: ... -
Preclinical molecular signatures of spinal cord functional restoration: Optimizing the metamorphic axolotl (ambystoma mexicanum) model in regenerative medicine
(Mary Ann Liebert, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ... -
Preoperative risk factors of airway complications in adult lung transplant recipients: A systematic review and meta-analysis
(Baycinar Medical Publishing, 2023)Background: In this systematic review and meta-analysis, we aimed to identify recipient-related preoperative risk factors for airway complications following lung transplantation in adults. Methods: Articles published between ... -
Preoperative screening for COVID-19: Results from a clinical diagnostic laboratory
(Istanbul University, 2022)Objective: The study aimed to determine what proportion of Turkiye’s preoperative patient population has tested positive for COVID-19 and to ascertain whether the increasing or decreasing trend in the numbers of positive ... -
Preservation of antegrade ejaculation after surgical relief of benign prostatic obstruction is a valid endpoint
(Springer, 2021)Purpose To review the current data on retrograde ejaculation (RE) and ejaculatory dysfunction (EjD) after endoscopic and minimally invasive surgical treatment of benign prostatic obstruction (BPO) and, their perceived ...
