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Toplam kayıt 340, listelenen: 157-176
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Health services management in Turkey: Failure or success?
(Wolters Kluwer Medknow Publications, 2019)Background: The unfair distribution and delivery of health-care resources have been recognized as a problem in the worldwide. In the past 18 years, Turkey has undergone rapid social, cultural, and economic changes. The ... -
Health-related quality of life in localized renal masses: A matter of sparing nephrons or minimizing the incision?
(Elsevier Science Inc, 2020)Purpose: Longitudinal assessment of health-related quality of life (HRQoL) differences in patients with localized renal masses according to treatment strategy. Methods: Consecutive patients >= 18 years with localized renal ... -
Herpes simplex virus and SLE: Though uncommon yet with significant implications
(NLM (Medline), 2023)To the Editor,The relation between infectious agents, particularly viruses, withautoimmunity and autoimmune diseases, has been extensivelystudied during the last decades. Recently, the association was shownto be even ... -
High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts
(Wiley, 2023)The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2-expressing cardiac afferent fibers of spinal ... -
Higher rates of COVID-19 but less severe infections reported for patients on dupilumab: A big data analysis of the world health organization vigibase
(Verduci Editore s.r.l, 2021)Objective: Dupilumab (Dupixent ®) is a monoclonal antibody that inhibits IL- 4 and IL-13 signaling used for the treatment of allergic diseases. Whilst biologic therapy is traditionally regarded as immunosuppressive and ... -
A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
(Elsevier GmbH, 2016)Axolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to ... -
Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
(American Society for Clinical Investigation Inc, 2018)Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show ... -
A homozygous TPO gene duplication (c. 1184_1187dup4) causes congenital hypothyroidism in three siblings born to a consanguineous family
(Georg Thieme Verlag, 2015)Congenital hypothyroidism (CH) is the most common neonatal endocrine disease, and germ-line mutations in the TPO gene cause the inherited form of the disease. Our aim in this study was to determine the genetic basis of ... -
Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
(Springer Heidelberg, 2022)The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (M Phi s) has been recently described as an unconventional role of M Phi s in the murine heart. Investigating the molecular and ... -
Identification of PDE10A related proteins via proteomic analysis
(İnönü University Faculty of Medicine, 2022)Aim: Phosphodiesterase 10A (PDE10A) regulates the expression of secondary messengers of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which control several intracellular signaling pathways. Recently, ... -
The IL-25/ILC2 axis promotes lung cancer with a concomitant accumulation of immune-suppressive cells in tumors in humans and mice
(Frontiers Media SA, 2023)Background: Group 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 cells help protect the host against helminth infection while exacerbating allergic-like inflammation ... -
Impact of adjuvant gemcitabine containing chemotherapy following radical nephroureterectomy for patients with upper tract urothelial carcinoma: Results from a propensity-score matched cohort study
(IOS Press BV, 2023)BACKGROUND: The evidence regarding perioperative adjuvant chemotherapy and personalized surveillance strategies for upper tract urothelial carcinoma is limited. OBJECTIVE: To evaluate whether adjuvant gemcitabine ... -
The impact of chiral switch on drug labeling in Turkey: Indication, posology, and adverse effects
(Marmara University, 2023)Objective: Chiral switch, which involves replacing racemic drugs to market them as pure enantiomers, is presumed to improve efficacy and safety. Data on how chiral switch-related changes are represented in summary of product ... -
The impact of cigarette smoking, water-pipe use on hearing loss/hearing impairment: A cross-sectional study
(Asian Pacific Organization for Cancer Prevention, 2024)OBJECTIVE: The aim of the present study was to determine the association between cigarette smoking, waterpipe smoking, and co-morbidity diseases on hearing loss. METHODS: A cross-sectional study was conducted among 1015 ... -
The impact of COVID-19 on patients with chronic obstructive pulmonary disease
(Edizioni Minerva Medica, 2023)BACKGROUND: The aim of this study was to evaluate the risk of serious adverse outcomes in patients with chronic obstructive pulmonary disease (COPD) related to COVID-19 by stratifying the comorbidity status.METHODS: This ... -
Impact of COVID-19 on urology practice: A global perspective and snapshot analysis
(MDPI, 2020)The global impact of the 2019 novel coronavirus disease (COVID-19) pandemic on urology practice remains unknown. Self-selected urologists worldwide completed an online survey by the Societe Internationale d'Urologie (SIU). ... -
The impact of COVID-19 pandemic on mental health of health care workers
(Edizioni Minerva Medica, 2022)Background: this study investigated the impact of cOViD-19 on professional (hcWs) health care workers’ mental health and the prevalence of depression, anxiety, fear and stress related to their workload. METHODS: This is a ... -
The impact of metabolic syndrome on increased risk of thyroid nodules and size
(Sage Publications Inc, 2018)Aim: The present research aimed to determine the relation between metabolic syndrome (MetS) and thyroid volume and nodule prevalence among Turkish population patients. Methods: This retrospective cohort study was carried ... -
Impact of previous malignancy at diagnosis on oncological outcomes of upper tract urothelial carcinoma
(NLM (Medline), 2023)BACKGROUND: The evidence of prognostic factors and individualized surveillance strategies for upper tract urothelial carcinoma are still weak. OBJECTIVES: To evaluate whether the history of previous malignancy (HPM) affects ... -
The impact of single-use digital flexible cystoscope for double J removal on hospital costs and work organization: A multicentric evaluation
(SAGE Publications Ltd, 2023)Background: Isiris-alpha (R) is a single-use digital flexible cystoscope with an integrated grasper designed for double J (DJ) stent removal. Aim of this study was to conduct a multicentric evaluation of the costs and ...
