dc.contributor.author | Siafaka, Panoraia I. | |
dc.contributor.author | Okur Üstündağ, Neslihan | |
dc.contributor.author | Mone, Mariza | |
dc.contributor.author | Giannakopoulou, Spyridoula | |
dc.contributor.author | Er, Sevda | |
dc.contributor.author | Pavlidou, Eleni | |
dc.contributor.author | Karavas, Evangelos | |
dc.contributor.author | Bikiaris, Dimitrios N. | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:43Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:43Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Siafaka, P. I., Okur Üstündağ, N., Mone, M., Giannakopoulou, S., Er, S., Pavlidou, E. ... Bikiaris, D. N. (2016). Two different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes. International Journal Of Molecular Sciences, 17(3). https://dx.doi.org/10.3390/ijms17030282 | en_US |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://dx.doi.org/10.3390/ijms17030282 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2795 | |
dc.description | WOS: 000373712800026 | en_US |
dc.description | PubMed ID: 26927072 | en_US |
dc.description.abstract | In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(epsilon-caprolactone) (PCL) electrospun fibers and beta-cyclodextrin (beta-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for beta-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and beta-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | PCL | en_US |
dc.subject | Fibers | en_US |
dc.subject | Antifungal | en_US |
dc.subject | Voriconazole Drug | en_US |
dc.subject | Inclusion Complexation | en_US |
dc.title | Two different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes | en_US |
dc.type | article | en_US |
dc.relation.ispartof | International Journal Of Molecular Sciences | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3210-3747 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 3 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3390/ijms17030282 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |