dc.contributor.author | Babiloni, Claudio | |
dc.contributor.author | del Percio, Claudio | |
dc.contributor.author | Lizio, Roberta | |
dc.contributor.author | Noce, Giuseppe | |
dc.contributor.author | Lopez, Susanna | |
dc.contributor.author | Soricelli, Andrea | |
dc.contributor.author | Ferri, Raffaele | |
dc.contributor.author | Nobili, Flavio | |
dc.contributor.author | Arnaldi, Dario | |
dc.contributor.author | Fama, Francesco | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Orzi, Francesco | |
dc.contributor.author | Buttinelli, Carla | |
dc.contributor.author | Giubilei, Franco | |
dc.contributor.author | Onofrj, Marco | |
dc.contributor.author | Stocchi, Fabrizio | |
dc.contributor.author | Stirpe, Paola | |
dc.contributor.author | Fuhr, Peter | |
dc.contributor.author | Gschwandtner, Ute | |
dc.contributor.author | Ransmayr, Gerhard | |
dc.contributor.author | Garn, Heinrich | |
dc.contributor.author | Fraioli, Lucia | |
dc.contributor.author | Pievani, Michela | |
dc.contributor.author | Frisoni, Giovanni B. | |
dc.contributor.author | D'Antonio, Fabrizia | |
dc.contributor.author | de Lena, Carlo | |
dc.contributor.author | Güntekin, Bahar | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Bazar, Erol | |
dc.contributor.author | Yener, Görsev | |
dc.contributor.author | Emek Savaş, Derya Durusu | |
dc.contributor.author | Triggiani, Antonio Ivano | |
dc.contributor.author | Franciotti, Raffaella | |
dc.contributor.author | Taylor, John Paul | |
dc.contributor.author | Vacca, Laura | |
dc.contributor.author | de Pandis, Maria Francesca | |
dc.contributor.author | Bonanni, Laura | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:50:37Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:50:37Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Babiloni, C., del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. ... Bonanni, L. (2018). Abnormalities of resting-state functional cortical connectivity in patients with dementia due to alzheimer's and lewy body diseases: An EEG study. Neurobiology of Aging, 65, 18-40. https://dx.doi.org/10.1016/j.neurobiolaging.2017.12.023 | en_US |
dc.identifier.issn | 0197-4580 | |
dc.identifier.issn | 1558-1497 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.neurobiolaging.2017.12.023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2033 | |
dc.description | WOS: 000428233700003 | en_US |
dc.description | PubMed ID: 29407464 | en_US |
dc.description.abstract | Previous evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Hold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values>0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. | en_US |
dc.description.sponsorship | H2020 Marie S. Curie ITN-ETN project | en_US |
dc.description.sponsorship | The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bddiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Functional Brain Connectivity | en_US |
dc.subject | Resting State EEG Rhythms | en_US |
dc.subject | Neurodegenerative Diseases | en_US |
dc.subject | Dementia | en_US |
dc.subject | Alzheimer's Disease | en_US |
dc.subject | Parkinson's Disease | en_US |
dc.subject | Dementia With Lewy Bodies | en_US |
dc.title | Abnormalities of resting-state functional cortical connectivity in patients with dementia due to alzheimer's and lewy body diseases: An EEG study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Neurobiology of Aging | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.identifier.volume | 65 | en_US |
dc.identifier.startpage | 18 | en_US |
dc.identifier.endpage | 40 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.neurobiolaging.2017.12.023 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |