Investigation of NF-kB1 and NF-kBIA gene polymorphism in non-small cell lung cancer
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessAttribution 3.0 Unportedhttps://creativecommons.org/licenses/by/3.0/Tarih
2014Yazar
Müşteri Oltulu, YaseminÇoşkunpınar, Ender Mehmet
Özkan, Gökhan
Aynacı, Engin
Yıldız, Pınar Birsen
İşbir, Turgay
Yaylım, İlhan
Üst veri
Tüm öğe kaydını gösterKünye
Müşteri Oltulu, Y., Çoşkunpınar, E. M., Özkan, G., Aynacı, E., Yıldız, P. B., İşbir, T. ... Yaylım, İ. (2014). Investigation of NF-kB1 and NF-kBIA gene polymorphism in non-small cell lung cancer. BioMed Research International, 2014. https://dx.doi.org/10.1155/2014/530381Özet
Lung cancer is a complex, multifactorial disease which is the leading cause of cancer death in both men and women. NF-B is a transcription factor which is known to affect the expression of more than 150 genes related to inflammation, lymphocyte activation, cell proliferation, differentiation, and apoptosis, as well as contributing to cell apoptosis and survival. However, NF-BIA (IB?) is the inhibitor of the transcription factor. The -94ins/delATTG polymorphism of the NF-B1 gene promoter region which causes a functional effect and NF-BIA 3'UTR A › G polymorphism has been shown to be related to various inflammatory diseases and cancer. Ninety-five NSCLC patients and 99 healthy controls were included in study. The NF-B1 -94ins/delATTG and NF-BIA 3'UTR A › G polymorphism have been studied by using PCR-RFLP method. It was found that the NF-B1 -94ins/delATTG DD genotype and D allele frequencies were higher in patients than healthy controls and the presence of the DD genotype has a 3.5-fold increased risk of the disease (P: 0.014). This study is the first to investigate the NF-B1 -94ins/delATTG and NF-BIA 3'UTR A › G polymorphism together in the Turkish population. According to the results, the NF-B1 -94ins/del ATTG promoter polymorphism may have a role in lung carcinogenesis and prognosis.
WoS Q Kategorisi
Q2Scopus Q Kategorisi
Q2Kaynak
BioMed Research InternationalCilt
2014Koleksiyonlar
- Makale Koleksiyonu [3691]
- PubMed İndeksli Yayınlar Koleksiyonu [4105]
- Scopus İndeksli Yayınlar Koleksiyonu [6383]
- WoS İndeksli Yayınlar Koleksiyonu [6506]