dc.contributor.author | Sönmez, Saadet | |
dc.contributor.author | Menevşe, Esma | |
dc.contributor.author | Baltacı, Saltuk Buğra | |
dc.contributor.author | Ünal, Ömer | |
dc.contributor.author | Moğulkoç, Rasim | |
dc.contributor.author | Baltacı, Abdulkerim Kasım | |
dc.date.accessioned | 2024-03-15T10:40:06Z | |
dc.date.available | 2024-03-15T10:40:06Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Sönmez, S., Menevşe, E., Baltacı, S. B., Ünal, Ö., Moğulkoç, R. ve Baltacı, A. K. (2023). Effects of pinealectomy and melatonin application on Serum Melatonin, Nesfatin-1 and ghrelin levels. European Journal of Therapeutics, 29(3), 526-533. https://dx.doi.org/10.58600/eurjther1747 | en_US |
dc.identifier.issn | 2564-7784 | |
dc.identifier.issn | 2564-7040 | |
dc.identifier.uri | https://dx.doi.org/10.58600/eurjther1747 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12371 | |
dc.description.abstract | Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats.
Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals.
Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01).
Conclusion: The findings of the study draw attention to an important relationship between the endocrine activity of the pineal gland and the hormones ghrelin and nesfatin-1, which play a critical role in nutrition. Consequently, administration of melatonin inhibits ghrelin but increases nesfatin-1. | en_US |
dc.description.sponsorship | 15202028 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Pera Publishing Services | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Pinealectomy | en_US |
dc.subject | Melatonin | en_US |
dc.subject | Nutrition | en_US |
dc.subject | Nesfatin-1 | en_US |
dc.subject | Ghrelin | en_US |
dc.subject | Rat | en_US |
dc.title | Effects of pinealectomy and melatonin application on Serum Melatonin, Nesfatin-1 and ghrelin levels | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Journal of Therapeutics | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-9752-7508 | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 526 | en_US |
dc.identifier.endpage | 533 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.58600/eurjther1747 | en_US |
dc.institutionauthor | Baltacı, Saltuk Buğra | |
dc.identifier.wos | 001158410800035 | en_US |
dc.identifier.trdizinid | 1199980 | en_US |