dc.contributor.author | Baydar, Rengin | |
dc.contributor.author | Karadağ, Ayşe Esra | |
dc.contributor.author | Biltekin, Sevde Nur | |
dc.contributor.author | Güzelmeriç, Etil | |
dc.contributor.author | Demirci, Fatih | |
dc.date.accessioned | 2024-02-07T12:03:50Z | |
dc.date.available | 2024-02-07T12:03:50Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Baydar, R., Karadağ, A. E., Biltekin, S. N., Güzelmeriç, E. ve Demirci, F. (2024). In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide. Acta Pharmaceutica Sciencia, 62(1), 183-192. https://dx.doi.org/10.23893/1307-2080.APS6212 | en_US |
dc.identifier.issn | 1307-2080 | |
dc.identifier.uri | https://dx.doi.org/10.23893/1307-2080.APS6212 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12249 | |
dc.description.abstract | Tanacetum parthenium L. (Feverfew) is daisy-like Asteraceae plant carrying sesquiterpene lactones; used for the treatment of migraine and anti-inflamma-tory effect. This study aims to evaluate T. parthenium extract and major metabolite parthenolide for in vitro COX-1/COX-2, LOX inhibitory activity. The extract analyzed by HPTLC. To evaluate COX-1/COX-2 inhibition assays, stud-ied with commercial kits (20µg/mL concentration for extract, 5 µg/mL for par-thenolide). The major component of extract characterized as parthenolide. IC50 values for COX-1/COX-2 inhibition of extract were 10.45 and 9.81µg/mL, for parthenolide; 4.86 and 1.90µg/mL. SI values of T. parthenium extract and par-thenolide were 0.93 and 0.39. Extract showed selective COX-2 inhibitory activ-ity. The inhibition value of extract on LOX was 80% and inhibition value of par-thenolide was 41.13%. The results suggested that T. parthenium extract showed selective potential for COX-2 enzyme inhibition. To the best of our knowledge, the extract was tested with COX-1, COX-2, and LOX enzymes for the first time. | en_US |
dc.description.sponsorship | Istanbul Medipol University Scientific Research Project Commisssion | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Istanbul Medipol University | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anti-Inflammatory | en_US |
dc.subject | COX | en_US |
dc.subject | Feverfew | en_US |
dc.subject | LOX | en_US |
dc.subject | Tanacetum Parthenium | en_US |
dc.title | In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0009-0008-3754-0293 | en_US |
dc.authorid | 0000-0002-3412-0807 | en_US |
dc.authorid | 0000-0003-1896-2729 | en_US |
dc.authorid | 0000-0001-9696-3271 | en_US |
dc.identifier.volume | 62 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 183 | en_US |
dc.identifier.endpage | 192 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23893/1307-2080.APS6212 | en_US |
dc.institutionauthor | Baydar, Rengin | |
dc.institutionauthor | Karadağ, Ayşe Esra | |
dc.institutionauthor | Biltekin, Sevde Nur | |
dc.institutionauthor | Güzelmeriç, Etil | |
dc.identifier.scopus | 2-s2.0-85183028761 | en_US |
dc.identifier.scopusquality | Q3 | en_US |