Importance of physiological oxygen levels for endothelial redox signaling using Hyper 7
Künye
Altun, H. Y., Yang, F., Mann, G. ve Eroğlu, E. (2023). Importance of physiological oxygen levels for endothelial redox signaling using Hyper 7. Free Radical Biology and Medicine içinde (S8-S9. ss.). Punta del Este, Uruguay, 15-18 November, 2023. https://dx.doi.org/10.1016/j.freeradbiomed.2023.10.018Özet
Cellular redox status is tightly linked to ambient oxygen levels. Endothelial cells (EC) in vivo are exposed to O2 levels between 3- 13 kPa, yet the majority in vitro studies maintain EC under atmospheric O2 levels (~18 O2). Under 18 kPa O2, EC are exposed to hyperoxia, leading to persistent upregulation of NRF2 regulated antioxidant defences. Exposure of EC to physiological O2 levels for at least 5 days attenuates NRF2-regulated antioxidant gene expression in the absence of HIF-1a stabilisation.
WoS Q Kategorisi
Q1Kaynak
Free Radical Biology and MedicineCilt
208Sayı
Supplement: 1Bağlantı
https://dx.doi.org/10.1016/j.freeradbiomed.2023.10.018https://hdl.handle.net/20.500.12511/12077