dc.contributor.author | Erşahan, Şeyda | |
dc.contributor.author | Özçelik, Fatih | |
dc.contributor.author | Şirin, Dursun Ali | |
dc.contributor.author | Erdem Hepsenoğlu, Yelda | |
dc.contributor.author | Özçelik, İlbey Kayra | |
dc.contributor.author | Topbaş, Celalettin | |
dc.date.accessioned | 2023-10-05T10:48:56Z | |
dc.date.available | 2023-10-05T10:48:56Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Erşahan, Ş., Özçelik, F., Şirin, D. A., Erdem Hepsenoğlu, Y., Özçelik, İ. K. ve Topbaş, C. (2023). Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease? Odontology, 111(3), 708-718. https://doi.org/10.1007/s10266-022-00767-9 | en_US |
dc.identifier.issn | 1618-1247 | |
dc.identifier.issn | 1618-1255 | |
dc.identifier.uri | https://doi.org/10.1007/s10266-022-00767-9 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11529 | |
dc.description.abstract | To investigate the relationship between apical periodontitis [AP] severity and inflammatory markers [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-α), and Mid-Regional Pro Adrenomedullin (MR-proADM)] in patients with AP. A total of 162 subjects were divided into three categories: AP group (n = 80), periodontitis (P) group (n = 42), healthy control group (n = 40). The scoring of disease severity in 80 AP patients without any periodontal disease, using dental radiographs, was based on “The Abscess Score” (AS), as those having at least 1 tooth with AP and severity of PAI 3–4 were classified as AS 1 (mild); those with only1 tooth and severity of PAI 5 as AS 2 (moderate) and those having > 2 tooth with severity of PAI 5 as AS 3 (severe). Blood samples were collected from all of the patients. Enzyme-linked immunosorbent assay was used to evaluate the samples. The MR-pro ADM levels of both the AP and P groups were considerably higher than the control group (p < 0.01). The IL-12 levels of the AP group were higher than the P and control groups (p < 0.05). TNF-α levels of the P group were significantly higher than both the AP and control groups (p < 0.01). MR-pro ADM levels of both the AP and Periodontitis groups were higher than the control group. TNF-α was a biomarker of periodontitis, while IL-12 was a biomarker of apical periodontitis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Apical Periodontitis | en_US |
dc.subject | Chronic Periodontitis | en_US |
dc.subject | IL-12 | en_US |
dc.subject | Mid Regional Proadrenomedullin | en_US |
dc.subject | TNF-α | en_US |
dc.title | Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease? | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Odontology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0354-5108 | en_US |
dc.authorid | 0000-0003-1844-1288 | en_US |
dc.identifier.volume | 111 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 708 | en_US |
dc.identifier.endpage | 718 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s10266-022-00767-9 | en_US |
dc.institutionauthor | Erşahan, Şeyda | |
dc.institutionauthor | Erdem Hepsenoğlu, Yelda | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | 000886450500001 | en_US |
dc.identifier.scopus | 2-s2.0-85142229733 | en_US |
dc.identifier.pmid | 36414882 | en_US |