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An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19

dc.contributor.authorKarataş, Hacer
dc.contributor.authorHanashalshahaby, Essam Hamied Ahmed
dc.contributor.authorÇatal, Ünal
dc.contributor.authorBütün, Yaşar Enes
dc.contributor.authorKurt, Elif
dc.contributor.authorGürsel, Şahin
dc.contributor.authorKaya, Adil
dc.contributor.authorGüzel, Mustafa
dc.date.accessioned2023-10-05T06:55:10Z
dc.date.available2023-10-05T06:55:10Z
dc.date.issued2023en_US
dc.identifier.citationKarataş, H., Hanashalshahaby, E. H. A., Çatal, Ü., Bütün, Y. E., Kurt, E., Gürsel, Ş. ... Güzel, M. (2023). An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19. Chemical Papers, 77(3), 1695-1702. https://doi.org/10.1007/s11696-022-02595-1en_US
dc.identifier.issn0366-6352
dc.identifier.issn2585-7290
dc.identifier.urihttps://doi.org/10.1007/s11696-022-02595-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11522
dc.description.abstractFavipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic strategies for favipiravir synthesis, economical procedures could contribute to industrial scale synthesis and availability. Accordingly, our efforts focused on an economic and scalable procedure for favipiravir synthesis via the 3,6-dichloropyrazine-2-carbonitrile intermediate obtained from 3-aminopyrazine-2-carboxylic acid. The process afforded favipiravir with 43% yield (from 3,6-dichloropyrazine-2-carbonitrile, by fluorination, hydroxylation, and nitrile hydrolysis reactions) and greater than 99% purity without a chromatographic purification step. Graphical abstract: [Figure not available: see fulltext.]en_US
dc.description.sponsorshipATABAY Fine Chemicals and Pharmaceutical Companyen_US
dc.language.isoengen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFavipiravir Synthesisen_US
dc.subject3,6-Dichloropyrazine-2-Carbonitrileen_US
dc.subjectCovid-19 Treatmenten_US
dc.subjectProcess Developmenten_US
dc.subjectActive Pharmaceutical Ingredient (API) Synthesisen_US
dc.titleAn economical and practical procedure of favipiravir synthesis for the treatment of Covid-19en_US
dc.typearticleen_US
dc.relation.ispartofChemical Papersen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Moleküler Tıp ve Biyoteknoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-7577-0320en_US
dc.authorid0000-0002-1423-0435en_US
dc.identifier.volume77en_US
dc.identifier.issue3en_US
dc.identifier.startpage1695en_US
dc.identifier.endpage1702en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/18AG020
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s11696-022-02595-1en_US
dc.institutionauthorKarataş, Hacer
dc.institutionauthorBütün, Yaşar Enes
dc.institutionauthorGüzel, Mustafa
dc.identifier.wosqualityQ3en_US
dc.identifier.wos000886743800001en_US
dc.identifier.scopus2-s2.0-85142345509en_US
dc.identifier.pmid36466109en_US
dc.identifier.scopusqualityQ2en_US


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