An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessTarih
2023Yazar
Karataş, HacerHanashalshahaby, Essam Hamied Ahmed
Çatal, Ünal
Bütün, Yaşar Enes
Kurt, Elif
Gürsel, Şahin
Kaya, Adil
Güzel, Mustafa
Üst veri
Tüm öğe kaydını gösterKünye
Karataş, H., Hanashalshahaby, E. H. A., Çatal, Ü., Bütün, Y. E., Kurt, E., Gürsel, Ş. ... Güzel, M. (2023). An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19. Chemical Papers, 77(3), 1695-1702. https://doi.org/10.1007/s11696-022-02595-1Özet
Favipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic strategies for favipiravir synthesis, economical procedures could contribute to industrial scale synthesis and availability. Accordingly, our efforts focused on an economic and scalable procedure for favipiravir synthesis via the 3,6-dichloropyrazine-2-carbonitrile intermediate obtained from 3-aminopyrazine-2-carboxylic acid. The process afforded favipiravir with 43% yield (from 3,6-dichloropyrazine-2-carbonitrile, by fluorination, hydroxylation, and nitrile hydrolysis reactions) and greater than 99% purity without a chromatographic purification step. Graphical abstract: [Figure not available: see fulltext.]
WoS Q Kategorisi
Q3Scopus Q Kategorisi
Q2Kaynak
Chemical PapersCilt
77Sayı
3Koleksiyonlar
- Diğer Yayınlar Koleksiyonu [257]
- Makale Koleksiyonu [276]
- Makale Koleksiyonu [331]
- Makale Koleksiyonu [176]
- PubMed İndeksli Yayınlar Koleksiyonu [4069]
- Scopus İndeksli Yayınlar Koleksiyonu [6313]
- WoS İndeksli Yayınlar Koleksiyonu [6455]