Inherited transmission of the CSF3R T618I mutation: A familial report
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Erişim
info:eu-repo/semantics/embargoedAccessTarih
2023Yazar
Serin, istemiCinli, Tahir Alper
Tunç, Sertaç
Kaynar, Leylagül
Sevindik, Ömür Gökmen
Yokuş, Osman
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Serin, İ., Cinli, T. A., Tunç, S., Kaynar, L., Sevindik, Ö. G. ve Yokuş, O. (2023). Inherited transmission of the CSF3R T618I mutation: A familial report. Annals of Hematology, 102(2), 477-479. https://doi.org/10.1007/s00277-022-05050-zÖzet
To the editor,
Chronic neutrophilic leukemia (CNL) is a rare, break cluster region-Abelson 1 (BCR-ABL1) negative myeloproliferative neoplasm, which is characterized by mature neutrophilic proliferation with neutrophilic hyperplasia in bone marrow and hepatosplenomegaly [1]. The disease is frequently diagnosed at an advanced age; therefore, the median age of diagnosis was reported as 66.5 [2]. There are a few features that distinguish CNL from chronic myeloid leukemia (CML), such as more mature granulopoietic forms compared to CML, the preponderance of granulocytes (≥ 80%) at the segmented or band stage of maturation, and minimal to no circulating blasts [1, 2]. Deterioration of thrombocytopenia along with increasing splenomegaly points out disease progression or blastic crisis [2].