Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Tarih
2022Üst veri
Tüm öğe kaydını gösterKünye
Parlar Köprülü, R. E., Okur, M. E., Kolbaşı, B., Keskin, İ. ve Özbek, H. (2022). Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats. Iranian Journal of Pharmaceutical Research, 21(1). https://dx.doi.org/10.5812/ijpr-132265Özet
Background: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. Objectives: This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis. Methods: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen’s score. Results: Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg group. Conclusions: It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis.
WoS Q Kategorisi
Q4Scopus Q Kategorisi
Q2Kaynak
Iranian Journal of Pharmaceutical ResearchCilt
21Sayı
1Koleksiyonlar
- Makale Koleksiyonu [3667]
- PubMed İndeksli Yayınlar Koleksiyonu [4073]
- Scopus İndeksli Yayınlar Koleksiyonu [6325]
- WoS İndeksli Yayınlar Koleksiyonu [6461]