Clinical course of psoriasis patients that discontinued biologics during the COVID-19 pandemic
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/Tarih
2023Yazar
Topaloğlu Demir, FilizEkinci, Algün Polat
Aytekin, Sema
Topkarcı, Zeynep
Aslan Kayıran, Melek
Özkök Akbulut, Tuğba
Topal, İlteriş Oğuz
Sarıkaya Solak, Sezgi
Kara Polat, Asude
Karadağ, Ayşe Serap
Üst veri
Tüm öğe kaydını gösterKünye
Topaloğlu Demir, F., Ekinci, A. P., Aytekin, S., Topkarcı, Z., Aslan Kayıran, M., Özkök Akbulut, T. ... Karadağ, A. S. (2023). Clinical course of psoriasis patients that discontinued biologics during the COVID-19 pandemic. Journal of Cosmetic Dermatology, 22(3), 722-731. https://dx.doi.org/10.1111/jocd.15638Özet
BackgroundSince psoriasis is a chronic disease, it is not recommended to discontinue the treatment agents used. However, in real life, the treatment of psoriasis patients may be interrupted for various reasons. During the pandemic period, the treatment of many patients was also interrupted. ObjectivesTo evaluate relapse and clinical worsening in psoriasis patients whose biological therapy was interrupted during the pandemic and reveal associated factors. MethodsThe study included patients aged >= 18 years, who were followed up with moderate and severe chronic psoriasis controlled by the last biological agent [Psoriasis Area Severity Index (PASI) 75 response achieved] but had to discontinue their treatment during the pandemic. The patients' demographic and clinical characteristics, clinical course after the discontinuation of these agents, presence of clinical worsening, and relapse were evaluated. Risk factors were analyzed with the logistic regression analysis. ResultsThe study included 169 patients, with a mean age of 47.3 +/- 14.5 (18-87) years. The mean biologics-free time was 18.2 +/- 12.3 (2-56) weeks. Clinical worsening was detected in 41.4% and relapse in 48.5% of the patients. The significant risk factors for clinical worsening and relapse in both univariate and multivariate analyses were alcohol use during the biologics-free period, total time off biologics, and the presence of an additional triggering factor. The use of secukinumab and ustekinumab was found to be a protective factor against clinical worsening in multivariate analyses. ConclusionAs the biologics-free period is prolonged, the likelihood of clinical worsening and relapse increases, therefore, we do not recommend discontinuing biological agents.
WoS Q Kategorisi
Q3Scopus Q Kategorisi
Q2Kaynak
Journal of Cosmetic DermatologyCilt
22Sayı
3Koleksiyonlar
- Makale Koleksiyonu [3701]
- PubMed İndeksli Yayınlar Koleksiyonu [4120]
- Scopus İndeksli Yayınlar Koleksiyonu [6404]
- WoS İndeksli Yayınlar Koleksiyonu [6516]