Yazar "Güzel, Mustafa" için listeleme
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Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)
Lee, Eunmi; Ouzounova, Maria D.; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John K.; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan (Nature Publishing Group, 2019)Following publication of this article the authors noted that the Acknowledgments section had been omitted. This section should read as follows. -
Cytotoxic activity and docking studies of 2-arenoxybenzaldehyde N-acyl hydrazone and 1,3,4-oxadiazole derivatives against various cancer cell lines
Aydın, Esranur; Şentürk, Ahmet Mesut; Başpınar Küçük, Hatice; Güzel, Mustafa (MDPI, 2022)To understand whether previously synthesized novel hydrazone and oxadiazole derivatives have promising anticancer effects, docking studies and in vitro toxicity assays were performed on A-549, MDA-MB-231, and PC-3 cell ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
Giray, Betül; Karadağ, Ayşe Esra; Şavluğ İpek, Özgecan; Pekel, Hanife; Güzel, Mustafa; Başpınar Küçük, Hatice (Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Determination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive
Erol, Kübra Feyza; Kutlu, Gözde; Tornuk, Fatih; Güzel, Mustafa; Dönmez, İlhami Emrah (Akademiai Kiado Zrt., 2023)Turkish red pine (Pinus brutia Ten.) is an important tree species that grows widely in Turkiye. In this study, Box-Behnken experimental design was created and optimised for ultrasound assisted extraction of bioactive ... -
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Gül, Şeref; Akyel, Yasemin Kübra; Gül, Zeynep Melis; Işın, Şafak; Özcan, Onur; Korkmaz, Tuba; Selvi, Saba; Danış, İbrahim; Şavluğ İpek, Özgecan; Aygenli, Fatih; Taşkın, Ali Cihan; Akarlar, Büşra Aytül; Özlü, Nurhan; Öztürk, Nuri; Öztürk, Narin; Özer Ünal, Durişehvar; Güzel, Mustafa; Türkay, Metin; Okyar, Alper; Kavaklı, İbrahim Halil (Nature Research, 2022)Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease ... -
An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19
Karataş, Hacer; Hanashalshahaby, Essam Hamied Ahmed; Çatal, Ünal; Bütün, Yaşar Enes; Kurt, Elif; Gürsel, Şahin; Kaya, Adil; Güzel, Mustafa (Springer Science and Business Media Deutschland GmbH, 2023)Favipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic strategies for favipiravir synthesis, economical procedures could ... -
The effects of increased glucose level and glycolysis on SARS CoV-2 infection
Zurnacı, Fatma Özlem; Güzel, Mustafa (Bentham Science Publishers, 2022)COVID-19 has entered our lives as an infection with high mortality rates. Although the vaccination process has provided benefits, the death toll remains frightening worldwide. Therefore, drugs and combined therapies that ... -
An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine
Başpınar Küçük, Hatice; Alhonaish, Anoud; Yıldız, Tülay; Güzel, Mustafa (Wiley-VCH Verlag, 2022)An oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o was employed to synthesize new 2,5-disubstituted 1,3,4-oxadiazole compounds 4 a-d, 4 f-i, 4 k-n. This method involves oxidative cyclization of ... -
Essential parameters and risk factors of the patients for diabetes care and treatment
Bener, Abdulbari; Keskin, Fatma Ela; Kurtuluş, Eda Merve; Güzel, Mustafa; Çekirdekçi, Elif İjlal; Kadıoğlu, Pınar; Konukoğlu, Dildar; Öztürk, Mustafa (Elsevier Ltd, 2017)Aim: The aim was to explore the association between Type 2 Diabetes Mellitus [T2DM] treatment satisfactions of patients regarding their socio-economic, life-style, history medication and clinical outcome in a Turkish ... -
Ghrelin o-açil transferaz inhibisyonunun obezite üzerine etkisinin araştırılması
Burul, Şerife Betül (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Obezite, hiperlipidemi, Tip-2 DM, hipertansiyon ve koroner kalp hastalıklarına sebep olan kronik bir hastalıktır ve son yıllarda dünyada ve ülkemizde hasta sayısı hızlı bir şekilde artmaktadır. Obezite, beraberinde ekonomik ... -
Identification and in vitro bioactivity screening of some marine-derived fungi from Turkish coastlines
Heydari, Hajar; Konuklugil, Belma; Giray, Betül; Karadağ, Ayşe Esra; Güzel, Mustafa (Cahiers de Biologie Marine, 2020)The marine environment represents a great variety of conditions of pressure, temperature, salinity, and light depending on depth, latitude and interactions with the continental shelf. These extreme and variable conditions ... -
Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2
Doğan, Kübra; Erol, Ebru; Orhan, Müge Didem; Değirmenci, Zehra; Kan, Tuğçe; Güngör, Ayşen; Yaşa, Belkıs; Avşar, Timuçin; Çetin, Yüksel; Durdağı, Serdar; Güzel, Mustafa (Wiley, 2022)Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment ... -
Investigation of anticancer activities of potentially active small molecule drug candidate molecules
Aydın, Esranur (İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Cancer is defined as the uncontrolled division and proliferation of cells in any part of the body. The most frequently seen cancers are lung, breast, and prostate cancer. Small molecules can be used for treatment of cancer. ... -
Lamotrigine derivatives-synthesis, anti-cancer, and anti-MDR-bacterial activities
Khan, Mahroza Kanwal; Siddiqui, Hina; Sharif, Ruby; Güzel, Mustafa; Wahab, Atia-tul; Yousuf, Sammer; Choudhary, M. Iqbal (Elsevier B.V., 2022)A new series of quaternary ammonium salts 3–21 of lamotrigine (6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine) was synthesized via N-alkylation of lamotrigine using different benzyl bromides. The new analogues were ... -
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
Durdağı, Serdar; Avşar, Timuçin; Orhan, Müge Didem; Serhatlı, Müge; Balcıoğlu, Bertan Koray; Öztürk, Hasan Ümit; Kayabölen, Alişan; Çetin, Yüksel; Aydınlık, Şeyma; Bağcı-Önder, Tuğba; Tekin, Şaban; Demirci, Hasan; Güzel, Mustafa; Akdemir, Atilla; Çalış, Şeyma; Oktay, Lalehan; Tolu, İlayda; Bütün, Yaşar Enes; Erdemoğlu, Ece; Olkan, Alpsu; Tokay, Nurettin; Işık, Şeyma; Özcan, Ayşenur; Acar, Elif; Büyükkılıç, Şehriban; Yumak, Yeşim (Cell Press, 2022)Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In the current drug repurposing ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
Keskin, Elif; Üçışık, Mehmet Hikmet; Sucu, Bilgesu Onur; Güzel, Mustafa (MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ...