Yazar "Öztürk, Gürkan" için listeleme
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Active shrinkage protects neurons following axonal transection
Aydın, Mehmet Şerif; Bay, Sadık; Yiğit, Esra Nur; Özgül, Cemil; Kaval Oğuz, Elif; Yenidünya Konuk, Elçin; Ayşit, Neşe; Cengiz, Nureddin; Erdoğan, Ender; Him, Aydın; Koçak, Mehmet; Eroğlu, Emrah; Öztürk, Gürkan (Elsevier Inc., 2023)Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water ... -
The acute effect of different NAD plus precursors included in the combined metabolic activators
Li, Xiangyu; Yang, Hong; Jin, Han; Türkez, Hasan; Öztürk, Gürkan; Doğanay, Hamdi Levent; Zhang, Cheng; Nielsen, Jens; Uhlen, Mathias; Boren, Jan; Mardinoğlu, Adil (Elsevier Science Inc, 2023)NAD+ and glutathione precursors are currently used as metabolic modulators for improving the metabolic conditions associated with various human diseases, including non-alcoholic fatty liver disease, neurodegenerative ... -
Adult mouse dorsal root ganglia neurons form aberrant glutamatergic connections in dissociated cultures
Bayat, Fazlı Kemal; Polat Budak, Betül; Yiğit, Esra Nur; Öztürk, Gürkan; Gülçür, Halil Özcan; Güveniş, Albert (Public Library of Science, 2021)Cultured sensory neurons can exhibit complex activity patterns following stimulation in terms of increased excitability and interconnected responses of multiple neurons. Although these complex activity patterns suggest a ... -
Aksolotl rejenerasyonunun farklı evrelerinde miRNA profilinin bulunması ve bulunan miRNA'ların görevlerinin in-siliko analizi
Giriş ve Amaç: Rejenerasyon, fonksiyonel bir kayıp yaşamadan hasarlı dokunun, organın ya da uzvun restore edilmesi işlemidir. Su semenderlerinden olan Aksolotl kendisini öldürmeyecek iç organ, merkezi sinir sistemi ve uzuv ... -
Aksolotl ve fare arka kök ganglionlarının rejenerasyon kapasitelerinin karşılaştırılması
Server Sezer, Ayşe (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Aksolotl semender aile üyesi, rejenerasyon araştırmaları için çok değerli bir model hayvandır. Kopan ekstremitelerini tekrar büyütebilen aksolotl hem periferik hem de merkezi sinir sistemini başarıyla ve eksiksiz bir şekilde ... -
Aksotomi hasarının arka kök gangliyon nöronlarının membran gerginliğine etkisinin araştırılması
Bay, Sadık (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Periferik sinir hasarından sonra, arka kök gangliyonundaki nöronlar ve omurilik ve beyin sapındaki motor nöronlar büyük morfolojik ve moleküler değişimlere uğrarlar. Hasar sonucu aksonal dejenerasyon ve ağrı oluşmaktadır. ... -
Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach
Kazcı, Yusuf Enes; Şahoğlu Göktaş, Sevilay; Aydın, Mehmet Şerif; Karadoğan, Behnaz; Nebol, Aylin; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Elsevier B.V., 2022)Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional ... -
Axolotl cells and tissues enhances cutaneous wound healing in mice
Demircan, Turan; Keskin, İlknur; Günal, Yalçın; İlhan, Ayşe Elif; Kolbaşı, Bircan; Öztürk, Gürkan (2016)Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar ... -
Beyin ekstrasellüler matriksinin nörodejenerasyondaki rolünün alzheimer fare modelinde araştırılması
Gürel, Büşra (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Alzheimer hastalığında (AD), sinaptik yanıt mekanizmalarının ve sinaptik bağlantı stabilitesinin hasar gördüğü bilinmektedir. Son yıllarda yapılan çalışmalar, nöron ve glialar tarafından üretilen bazı ekstrasellüler matriks ... -
Bioinspired scaffold induced regeneration of neural tissue
Altun, Esra; Aydoğdu, Mehmet Onur; Toğay, Sine Özmen; Şengil, Ahmet Zeki; Ekren, Nazmi; Erginer Hasköylü, Merve; Toksoy Öner, Ebru; Altuncu, Neşe A.; Öztürk, Gürkan; Crabbe-Mann, Maryam; Ahmed, Jubair; Gündüz, Oğuzhan; Edirisinghe, Mohan (Pergamon-Elsevier Science Ltd, 2019)In the last decade, nerve tissue engineering has attracted much attention due to the incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold induced nanofibrous structures using both bio ... -
A co-culture-based multiparametric imaging technique to dissect local H2O2 signals with targeted HyPer7
Seçilmiş, Melike; Altun, Hamza Yusuf; Pilic, Johannes; Erdoğan, Yusuf Ceyhun; Çokluk, Zeynep; Ata, Büşra Nur; Sevimli, Gülşah; Zaki, Asal Ghaffari; Yiğit, Esra Nur; Öztürk, Gürkan; Malli, Roland; Eroğlu, Emrah (MDPI, 2021)Multispectral live-cell imaging is an informative approach that permits detecting biological processes simultaneously in the spatial and temporal domain by exploiting spectrally distinct biosensors. However, the combination ... -
A comparative study of fixatives for axolotl blastema tissue
Keskin, İlknur; Yıldırım, Berna; Kolbaşı, Bircan; Öztürk, Gürkan; Demircan, Turan (Soc Chilena Anatomia, 2017)Regeneration is defined as tissue renewal and functional restoration process of the damaged parts of the body after an injury. Ambystoma mexicanum, commonly named the Axolotl, is one of the unique vertebrates, which has a ... -
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
Sibai, Mustafa; Altuntaş, Ebru; Süzek, Barış Ethem; Şahin, Betül; Parlayan, Cüneyd; Öztürk, Gürkan; Baykal, Ahmet Tarık; Demircan, Turan (Elsevier, 2020)The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ... -
Complexities of the chemogenetic toolkit: Differential mDAAO activation by D-amino substrates and subcellular targeting
Erdoğan, Yusuf Can; Altun, Hamza Yusuf; Seçilmiş, Melike; Ata, Büşra N.; Sevimli, Gülşah; Çokluk, Zeynep; Zaki, Asal Ghaffari; Sezen, Serap; Akgül Çağlar, Tuba; Sevgen, İlker; Steinhorn, Benjamin; Ai, Huiwang; Öztürk, Gürkan; Belousov, Vsevelod V.; Michel, Thomas; Eroğlu, Emrah (Elsevier Inc., 2021)A common approach to investigate oxidant-regulated intracellular pathways is to add exogenous H2O2 to living cells or tissues. However, the addition of H2O2 to the culture medium of cells or tissues approach does not ... -
Consequences of neurite transection in vitro
Cengiz, Nurettin; Öztürk, Gürkan; Erdoǧan, Ender; Him, Aydın; Oğuz, Elif Kaval (Mary Ann Liebert Inc, 2012)In order to quantify degenerative and regenerative changes and analyze the contribution of multiple factors to the outcome after neurite transection, we cultured adult mouse dorsal root ganglion neurons, and with a precise ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
Demircan, Turan; Keskin, İlknur; Dumlu, Seda Nilgün; Aytürk, Nilüfer; Avşaroğlu, Mahmut Erhan; Akgün, Emel; Öztürk, Gürkan; Baykal, Ahmet Tarık (Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
Development of a chemogenetic approach to manipulate intracellular pH
Zaki, Asal Ghaffari; Miri, Seyed Mohammad; Çimen, Şeyma; Akgül Çağlar, Tuba; Yiğit, Esra Nur; Aydın, Mehmet S.; Öztürk, Gürkan; Eroğlu, Emrah (American Chemical Society, 2023)Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
Bay, Sadık; Öztürk, Gürkan; Emekli, Nesrin; Demircan, Turan (Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
Effect of LGI1 antibody-positive IgG on hippocampal neuron survival: A preliminary study
Ayşit Altuncu, Neşe; Ulusoy, Canan; Öztürk, Gürkan; Tüzün, Erdem (Lippincott Williams & Wilkins, 2018)Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is one of the most frequently encountered forms of autoimmune encephalitis. Many patients with anti-LGI1 encephalitis develop permanent hippocampal neuron ...