Yazar "Çankaya, Şeyda" için listeleme
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The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
Brain temperature in healthy and diseased conditions: A review on the special implications of MRS for monitoring brain temperature
Yulug, Burak; Velioğlu, Halil Aziz; Sayman, Dila; Çankaya, Şeyda; Hanoğlu, Lütfü (Elsevier Masson s.r.l., 2023)Brain temperature determines not only an individual's cognitive functionality but also the prognosis and mortality rates of many brain diseases. More specifically, brain temperature not only changes in response to different ... -
Chemogenetic inhibition of MCH neurons does not alter memory performance in mice
Mutlu Burnaz, Özlem; Yuluğ, Burak; Öncül, Merve; Çelik, Eşref; Sayar Atasoy, Nilüfer; Çankaya, Şeyda; Hanoğlu, Lütfü; Velioğlu, Halil Aziz (Elsevier Masson s.r.l., 2022)Memory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consolidation ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases
Türkez, Hasan; Altay, Özlem; Yıldırım, Serkan; Li, Xiangyu; Yang, Hong; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Arif, Muhammad; Yuluğ, Burak; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Hacımüftüoğlu, Ahmet; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Borén, Jan; Uhlén, Mathias; Mardinoğlu, Adil (Elsevier Inc., 2023)Background: Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data and animal studies ... -
A different view on the pathophysiology of Parkinson’s disease: A descendent neurochemical hypothesis?
Yuluğ, Burak; Ozansoy, Mehmet; Çankaya, Şeyda (Wolters Kluwer, 2019)It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN)neurons. Growing evidence suggests that there is a latent period of PD associated with slight ... -
The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model
Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakariş, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (University Press, 2022)Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative ... -
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ... -
The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
Yuluğ, Burak; Ayyıldız, Sevilay; Sayman, Dila; Karaca, Ramazan; İpek, Lütfiye; Çankaya, Şeyda; Salar, Ali Behram; Ayyıldız, Behçet; Mikuta, Christian; Yağcı, Nilay; Özdemir Öktem, Ece; Özşimşek, Ahmet; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (John Wiley and Sons Inc, 2024)INTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their ... -
Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
Yuluğ, Burak; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sayman, Dila; Salar, Ali Behram; Çankaya, Şeyda; Özdemir, Ece; Özşimşek, Ahmet; Kurt, Çağla Ceren; Lakadamyalı, Hatice; Aktürk, Aynur; Altay, Özlem; Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Mardinoğlu, Adil (John Wiley and Sons Inc, 2023)Although no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that ... -
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza; Yuluğ, Burak; Çankaya, Şeyda; Kılıç, Ertuğrul; Göktekin, Şule; Kılıç, Ülkan (Elsevier Science Ltd., 2020)Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ... -
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Çetin Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, Ülkan; Kılıç, Ertuğrul (2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ... -
More evidence for headache and spontaneous glabellar ecchymosis: Does the headache type or the treatment response matter? A neurovascular hypothesis
Yuluǧ, Burak; Işık, Doğan; Çankaya, Şeyda; Öktem, Ece Özdemir; Hanoğlu, Lütfü (Wiley, 2019)We present a 37-year-old man with erythema-like lesions, which devel-oped after two different headache episodes that had not responded tosumatriptan treatment and gradually resolved over the next few days. Thepatient ... -
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
Çankaya, Şeyda; Özdemir Öktem, Ece; Saatçi, Özlem; Velioğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method
Avnioğlu, Seda; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (Lippincott Williams & Wilkins, 2021)Background Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are ... -
The therapeutic role of minocycline in Parkinson's disease
Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ülkan; Kılıç, Ertuğrul; Yuluǧ, Burak (Bioexcel Publishing LTD, 2019)Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...