Yazar "Ünal, İsmail" için listeleme
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Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos
Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Wiley, 2018)Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure ... -
Microarray analysis to determine gene expression changes in zebrafish embryos
Ünal, İsmail; Beler, Merih; Cansız, Derya; Emekli Alturfan, Ebru (Humana Press Inc., 2024)Chemical exposure in humans begins from the zygote stage and continues throughout the development of the embryo and the fetus. Zebrafish are one of the most powerful model organisms used in many research areas, including ... -
Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epileptogenesis
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Alturfan, Ahmet Ata; Tiber, Pınar Mega; Emekli Alturfan, Ebru (Taylor and Francis Ltd., 2023)Zebrafish (Danio rerio) is becoming an increasingly important model in epilepsy research. Pentylenetetrazole (PTZ) is a convulsant agent that induces epileptic seizure-like state in zebrafish and zebrafish embryos and is ... -
Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity
Cansız, Derya; Üstündağ, Ünsal Veli; Ünal, İsmail; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)Parkinson's disease (PD) is one of the most common neurodegenerative diseases due to the loss of dopaminergic neurons in the midbrain in the substantia nigra. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a ... -
Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish
Ünal, İsmail; Çalışkan Ak, Esin; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Altınöz, Meriç Adil; Elmacı, İlhan; Emekli Alturfan, Ebru (Taylor and Francis Ltd, 2020)Aim: The aim of this study is to investigate the possible protective effects of mitoquinone and oleandrin on rotenone induced Parkinson’s disease in zebrafish. Materials and methods: Adult zebrafish were exposed to rotenone ... -
Oxidative stress and apoptosis in electromagnetic waves exposed Zebrafish embryos and protective effects of conductive nonwoven fabric
Üstündağ, Ünsal Veli; Özen, Mustafa Sabri; Ünal, İsmail; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Akalın, Mehmet; Sancak, Erhan; Emekli Alturfan, Ebru (CMB Association, 2020)The amount of technological products including television, radio transmitters, and mobile phone that have entered our daily life has increased in recent years. But these devices may cause adverse effects on human health. ... -
Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos
Karagöz, Atakan; Beler, Merih; Altun, Büşra Dilara; Ünal, İsmail; Cansız, Derya; Gündüz, Hüseyin; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru; Erçalık Yalçınkaya, Şebnem (Elsevier Masson s.r.l., 2023)Panoramic x-ray units are widely used in dental radiodiagnostics. Patients are exposed to relatively low radiation doses with panoramic imaging, but considering lifetime frequency of exposure, even a small risk can have ... -
Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish
Sürmen, Mustafa Gani; Sürmen, Saime; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2021)Ketosis is a potentially beneficial metabolic state for health especially in neurological conditions including Parkinson's disease (PD). Medium-chain-triglycerides (MCT) have specific metabolic properties and they are ... -
Quantitative real-time PCR method to evaluate gene expression in zebrafish embryos
Beler, Merih; Cansız, Derya; Ünal, İsmail; Emekli Alturfan, Ebru (Humana Press Inc., 2024)The fast zebrafish embryonic development offers an opportunity for the study of genes crucial for developmental processes. Several genes associated with human diseases have orthologs in zebrafish. Enhanced comprehension ... -
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
Yurtsever, İlknur; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ... -
Rotenone impairs oxidant/antioxidant balance both in brain and intestines in zebrafish
Ünal, İsmail; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Eğilmezer, Gizem; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2019)Aim of the study: Rotenone is a commonly used pesticide that inhibits complex I of the mitochondrial electron transport system. Rotenone exposed rats demonstrate many characteristics of Parkinson Disease (PD). Oxidative ... -
Sodium-dependent glucose co-transporter-2 inhibitor empagliflozin exerts neuroprotective effects in rotenone-induced Parkinson's disease model in zebrafish; mechanism involving ketogenesis and autophagy
Ünal, İsmail; Cansız, Derya; Beler, Merih; Sezer, Zehra; Güzel, Elif; Emekli Alturfan, Ebru (Elsevier B.V., 2023)Sodium-dependent glucose co-transporter-2 (SGLT2) inhibitor empagliflozin (EMP), is the new class of oral hypoglycemic agent approved as a treatment for Type 2 diabetes. SGLT2 inhibitors may induce ketogenesis through ... -
Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
Dandin, Esra; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Beler, Merih; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (Elsevier Ltd, 2022)Obesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have ... -
Stevioside improves brain oxidant-antioxidant status in overfed zebrafish
Dandin, Esra; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Cansız, Derya; Ateş Kalkan, Perihan Seda; Emekli Alturfan, Ebru (Istanbul University Press, 2023)Objective: An excessive buildup of adipose tissue is a defining feature of overnutrition, and a significant fraction of the world's population suffers from obesity. Overnutrition is associated with the deterioration of ... -
White LED light exposure inhibits the development and xanthophore pigmentation of zebrafish embryo
Üstündağ, Ünsal Veli; Çalışkan-Ak, Esin; Ateş, Perihan Seda; Ünal, İsmail; Eğilmezer, Gizem; Yiğitbaşı, Türkan; Alturfan, Ahmet Ata; Emekli-Alturfan, Ebru (Nature Publishing Group, 2019)Circadian rhythm in all living organisms is disturbed continuously by artificial light sources and artificial lighting has become a hazard for public health. Circadian rhythm of melatonin maintains high levels of melatonin ... -
Whole-mount RNA in situ hybridization of zebrafish embryos
Ünal, İsmail; Cansız, Derya; Beler, Merih; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Humana Press Inc., 2024)A commonly employed technique in molecular biology to evaluate the temporal and spatial expression of a certain gene is in situ hybridization. This method is an effective strategy to construct synexpression groups, ...