dc.contributor.author | Beuker, Carolin | |
dc.contributor.author | Schafflick, David | |
dc.contributor.author | Strecker, Jan-Kolja | |
dc.contributor.author | Heming, Michael | |
dc.contributor.author | Li, Xiaolin | |
dc.contributor.author | Wolbert, Jolien | |
dc.contributor.author | Schmidt-Pogoda, Antje | |
dc.contributor.author | Thomas, Christian | |
dc.contributor.author | Kuhlmann, Tanja | |
dc.contributor.author | Aranda-Pardos, Irene | |
dc.contributor.author | A-Gonzalez, Noelia | |
dc.contributor.author | Kumar, Praveen Ashok | |
dc.contributor.author | Werner, Yves | |
dc.contributor.author | Kılıç, Ertuğrul | |
dc.contributor.author | Hermann, Dirk M. | |
dc.contributor.author | Wiendl, Heinz | |
dc.contributor.author | Stumm, Ralf | |
dc.contributor.author | zu Hörste, Gerd Meyer | |
dc.contributor.author | Minnerup, Jens | |
dc.date.accessioned | 2022-02-25T07:43:06Z | |
dc.date.available | 2022-02-25T07:43:06Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Beuker, C., Schafflick, D., Strecker, Jan-K., Heming, M., Li, X., Wolbert, J. ... Minnerup, J. (2022). Stroke induces disease-specific myeloid cells in the brain parenchyma and pia. Nature Communications, 13(1), 945-945. http://doi.org/10.1038/s41467-022-28593-1 | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://doi.org/10.1038/s41467-022-28593-1 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9004 | |
dc.description.abstract | Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the post-ischemic immune response of border compartments compared to brain parenchyma remains poorly characterized. Here, we deeply characterize tissue-resident leukocytes in meninges and brain parenchyma and discover that leukocytes respond differently to stroke depending on their site of residence. We thereby discover a unique phenotype of myeloid cells exclusive to the brain after stroke. These stroke-associated myeloid cells partially resemble neurodegenerative disease-associated microglia. They are mainly of resident microglial origin, partially conserved in humans and exhibit a lipid-phagocytosing phenotype. Blocking markers specific for these cells partially ameliorates stroke outcome thus providing a potential therapeutic target. The injury-response of myeloid cells in the CNS is thus compartmentalized, adjusted to the type of injury and may represent a therapeutic target. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | NLM (Medline) | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Brain Parenchyma | en_US |
dc.subject | Pia | en_US |
dc.subject | Myeloid Cells | en_US |
dc.subject | Stroke Disease | en_US |
dc.title | Stroke induces disease-specific myeloid cells in the brain parenchyma and pia | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Nature Communications | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0001-6494-8923 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 945 | en_US |
dc.identifier.endpage | 945 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1038/s41467-022-28593-1 | en_US |
dc.institutionauthor | Kılıç, Ertuğrul | |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.wos | 000757851300022 | en_US |
dc.identifier.scopus | 2-s2.0-85124776410 | en_US |
dc.identifier.pmid | 35177618 | en_US |
dc.identifier.scopusquality | Q1 | en_US |