dc.contributor.author | Yurttaş, Leyla | |
dc.contributor.author | Demirayak, Şeref | |
dc.contributor.author | Çiftçi Akalın, Gülşen | |
dc.contributor.author | Yıldırım Ulusoylar, Şafak | |
dc.contributor.author | Kaplancıklı, Zafer Asım | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:35:33Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:35:33Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Yurttaş, L., Demirayak, Ş., Çiftçi Akalın, G., Yıldırım Ulusoylar, Ş. ve Kaplancıklı, Z. A. (2013). Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents. Archiv der Pharmazie, 346(5), 403-414. https://dx.doi.org/10.1002/ardp.201200452 | en_US |
dc.identifier.issn | 0365-6233 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/840 | |
dc.identifier.uri | https://dx.doi.org/10.1002/ardp.201200452 | |
dc.description.abstract | The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound was reacted with sulfur and morpholine via WillgerodtKindler reaction to give 2-[(morpholine-4-yl)thioxomethyl]benzimidazole. Then, the obtained compound was reacted with appropriate -bromoacetophenone derivatives in the presence of potassium carbonate to give the final products. Structure elucidation of the final compounds was achieved by FT-IR, 1H NMR spectroscopy and MS spectrometry. The anticancer activities of the final compounds were evaluated by MTT assay, BrdU method, and flow cytometric analysis on C6, MCF-7, and A549 tumor cells. Most of the synthesized compounds exhibited considerable selectivity against the MCF-7 and C6 cell lines. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anticancer Activity | en_US |
dc.subject | Benzimidazole | en_US |
dc.subject | Brdu | en_US |
dc.subject | Flow Cytometric Analysis | en_US |
dc.subject | Thioamide | en_US |
dc.title | Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Archiv der Pharmazie | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | en_US |
dc.identifier.volume | 346 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 403 | en_US |
dc.identifier.endpage | 414 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1002/ardp.201200452 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |